SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism
Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endotheli...
Gespeichert in:
| Veröffentlicht in: | Viruses Jg. 13; H. 11; S. 2209 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Switzerland
MDPI AG
03.11.2021
MDPI |
| Schlagworte: | |
| ISSN: | 1999-4915, 1999-4915 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endothelial injury are not defined. We determined the effects of SARS-CoV-2 spike protein-mediated endothelial injury under conditions of exposure to androgen dihydrotestosterone (DHT) and tumor necrosis factor-a (TNF-α) and tested potentially therapeutic effects of mineralocorticoid receptor antagonism by spironolactone. Circulating endothelial injury markers VCAM-1 and E-selectin were measured in men and women diagnosed with COVID-19. Exposure of endothelial cells (ECs) in vitro to DHT exacerbated spike protein S1-mediated endothelial injury transcripts for the cell adhesion molecules E-selectin, VCAM-1 and ICAM-1 and anti-fibrinolytic PAI-1 (p < 0.05), and increased THP-1 monocyte adhesion to ECs (p = 0.032). Spironolactone dramatically reduced DHT+S1-induced endothelial activation. TNF-α exacerbated S1-induced EC activation, which was abrogated by pretreatment with spironolactone. Analysis from patients hospitalized with COVID-19 showed concordant higher circulating VCAM-1 and E-Selectin levels in men, compared to women. A beneficial effect of the FDA-approved drug spironolactone was observed on endothelial cells in vitro, supporting a rationale for further evaluation of mineralocorticoid antagonism as an adjunct treatment in COVID-19. |
|---|---|
| AbstractList | Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endothelial injury are not defined. We determined the effects of SARS-CoV-2 spike protein-mediated endothelial injury under conditions of exposure to androgen dihydrotestosterone (DHT) and tumor necrosis factor-a (TNF-α) and tested potentially therapeutic effects of mineralocorticoid receptor antagonism by spironolactone. Circulating endothelial injury markers VCAM-1 and E-selectin were measured in men and women diagnosed with COVID-19. Exposure of endothelial cells (ECs) in vitro to DHT exacerbated spike protein S1-mediated endothelial injury transcripts for the cell adhesion molecules E-selectin, VCAM-1 and ICAM-1 and anti-fibrinolytic PAI-1 (p < 0.05), and increased THP-1 monocyte adhesion to ECs (p = 0.032). Spironolactone dramatically reduced DHT+S1-induced endothelial activation. TNF-α exacerbated S1-induced EC activation, which was abrogated by pretreatment with spironolactone. Analysis from patients hospitalized with COVID-19 showed concordant higher circulating VCAM-1 and E-Selectin levels in men, compared to women. A beneficial effect of the FDA-approved drug spironolactone was observed on endothelial cells in vitro, supporting a rationale for further evaluation of mineralocorticoid antagonism as an adjunct treatment in COVID-19. Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endothelial injury are not defined. We determined the effects of SARS-CoV-2 spike protein-mediated endothelial injury under conditions of exposure to androgen dihydrotestosterone (DHT) and tumor necrosis factor-a (TNF-α) and tested potentially therapeutic effects of mineralocorticoid receptor antagonism by spironolactone. Circulating endothelial injury markers VCAM-1 and E-selectin were measured in men and women diagnosed with COVID-19. Exposure of endothelial cells (ECs) in vitro to DHT exacerbated spike protein S1-mediated endothelial injury transcripts for the cell adhesion molecules E-selectin, VCAM-1 and ICAM-1 and anti-fibrinolytic PAI-1 ( < 0.05), and increased THP-1 monocyte adhesion to ECs ( = 0.032). Spironolactone dramatically reduced DHT+S1-induced endothelial activation. TNF-α exacerbated S1-induced EC activation, which was abrogated by pretreatment with spironolactone. Analysis from patients hospitalized with COVID-19 showed concordant higher circulating VCAM-1 and E-Selectin levels in men, compared to women. A beneficial effect of the FDA-approved drug spironolactone was observed on endothelial cells in vitro, supporting a rationale for further evaluation of mineralocorticoid antagonism as an adjunct treatment in COVID-19. Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endothelial injury are not defined. We determined the effects of SARS-CoV-2 spike protein-mediated endothelial injury under conditions of exposure to androgen dihydrotestosterone (DHT) and tumor necrosis factor-a (TNF-α) and tested potentially therapeutic effects of mineralocorticoid receptor antagonism by spironolactone. Circulating endothelial injury markers VCAM-1 and E-selectin were measured in men and women diagnosed with COVID-19. Exposure of endothelial cells (ECs) in vitro to DHT exacerbated spike protein S1-mediated endothelial injury transcripts for the cell adhesion molecules E-selectin, VCAM-1 and ICAM-1 and anti-fibrinolytic PAI-1 (p < 0.05), and increased THP-1 monocyte adhesion to ECs (p = 0.032). Spironolactone dramatically reduced DHT+S1-induced endothelial activation. TNF-α exacerbated S1-induced EC activation, which was abrogated by pretreatment with spironolactone. Analysis from patients hospitalized with COVID-19 showed concordant higher circulating VCAM-1 and E-Selectin levels in men, compared to women. A beneficial effect of the FDA-approved drug spironolactone was observed on endothelial cells in vitro, supporting a rationale for further evaluation of mineralocorticoid antagonism as an adjunct treatment in COVID-19.Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endothelial injury are not defined. We determined the effects of SARS-CoV-2 spike protein-mediated endothelial injury under conditions of exposure to androgen dihydrotestosterone (DHT) and tumor necrosis factor-a (TNF-α) and tested potentially therapeutic effects of mineralocorticoid receptor antagonism by spironolactone. Circulating endothelial injury markers VCAM-1 and E-selectin were measured in men and women diagnosed with COVID-19. Exposure of endothelial cells (ECs) in vitro to DHT exacerbated spike protein S1-mediated endothelial injury transcripts for the cell adhesion molecules E-selectin, VCAM-1 and ICAM-1 and anti-fibrinolytic PAI-1 (p < 0.05), and increased THP-1 monocyte adhesion to ECs (p = 0.032). Spironolactone dramatically reduced DHT+S1-induced endothelial activation. TNF-α exacerbated S1-induced EC activation, which was abrogated by pretreatment with spironolactone. Analysis from patients hospitalized with COVID-19 showed concordant higher circulating VCAM-1 and E-Selectin levels in men, compared to women. A beneficial effect of the FDA-approved drug spironolactone was observed on endothelial cells in vitro, supporting a rationale for further evaluation of mineralocorticoid antagonism as an adjunct treatment in COVID-19. |
| Author | Obi, Andrea T. Kumar, Nitin Kanthi, Yogendra Knight, Jason S. Zuo, Yu Yalavarthi, Srilakshmi Hunker, Kristina L. Ganesh, Santhi K. |
| AuthorAffiliation | 3 Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA; yzu@med.umich.edu (Y.Z.); syalavar@med.umich.edu (S.Y.); jsknight@med.umich.edu (J.S.K.) 1 Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; kumarni@med.umich.edu (N.K.); klhunker@med.umich.edu (K.L.H.); yogen.kanthi@nih.gov (Y.K.) 2 Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA 4 National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA 5 Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA; easta@med.umich.edu |
| AuthorAffiliation_xml | – name: 4 National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA – name: 3 Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA; yzu@med.umich.edu (Y.Z.); syalavar@med.umich.edu (S.Y.); jsknight@med.umich.edu (J.S.K.) – name: 5 Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA; easta@med.umich.edu – name: 1 Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; kumarni@med.umich.edu (N.K.); klhunker@med.umich.edu (K.L.H.); yogen.kanthi@nih.gov (Y.K.) – name: 2 Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA |
| Author_xml | – sequence: 1 givenname: Nitin orcidid: 0000-0003-0153-3493 surname: Kumar fullname: Kumar, Nitin – sequence: 2 givenname: Yu surname: Zuo fullname: Zuo, Yu – sequence: 3 givenname: Srilakshmi surname: Yalavarthi fullname: Yalavarthi, Srilakshmi – sequence: 4 givenname: Kristina L. surname: Hunker fullname: Hunker, Kristina L. – sequence: 5 givenname: Jason S. surname: Knight fullname: Knight, Jason S. – sequence: 6 givenname: Yogendra orcidid: 0000-0002-5660-5194 surname: Kanthi fullname: Kanthi, Yogendra – sequence: 7 givenname: Andrea T. orcidid: 0000-0001-7613-2366 surname: Obi fullname: Obi, Andrea T. – sequence: 8 givenname: Santhi K. surname: Ganesh fullname: Ganesh, Santhi K. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34835015$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkstuEzEUhkeoiF5gwQugkdjAYqhvc_EGKQotRGoFIsDW8thnEocZO7WdSHkfHrQeklZt2SAvbB1__6__2Oc0O7LOQpa9xugDpRydbzHFmBDEn2UnmHNeMI7Lowfn4-w0hBVCVcVR_SI7pqyhJcLlSfZnPvk-L6buV0Hy-dr8hvybdxGMzee4uAZtZASdX1jt4hJ6I_t8Zlcbv8ul1SNazGzXy2GQ0aXiPCY8n4V8Mqx705kkbXf5J7Pc6dE1RBci-BT-IIct2LiHro0FL3unnI9GOaPziY1y4awJw8vseSf7AK8O-1n28_Lix_RLcfX182w6uSpUiUgsgHCOCDRKIVbRDivJNdKN4qQkXdlUlWqBq1aXlHe8SqshLQcG0LQlI4TTs2y299VOrsTam0H6nXDSiL8F5xdCjul6EISDJKruFK9LRuuW15pIqWoOWCtadcnr495rvWkH0Co1mtp7ZPr4xpqlWLitaCpcN5gmg3cHA-9uNuntxGCCgr6XFtwmCFLRqmSorvl_oIghzCgb0bdP0JXbeJtedaQIYbxGZaLePAx_n_pubhJwvgeUdyF46IQy6e-NG3sxvcBIjJMp7iczKd4_UdyZ_sveAqv15B4 |
| CitedBy_id | crossref_primary_10_1038_s41587_022_01474_0 crossref_primary_10_1186_s12890_024_03013_w crossref_primary_10_3390_jcdd10060245 crossref_primary_10_1016_j_tim_2023_06_004 crossref_primary_10_3390_biomedicines10112706 crossref_primary_10_3390_microorganisms12020272 crossref_primary_10_3390_ijerph19095277 crossref_primary_10_3390_v14071425 crossref_primary_10_1002_jmv_28568 crossref_primary_10_1071_MA24005 crossref_primary_10_3389_fimmu_2022_827146 crossref_primary_10_1038_s41401_022_00998_0 crossref_primary_10_1016_j_biochi_2024_09_010 crossref_primary_10_1016_j_molmed_2022_04_007 crossref_primary_10_3390_ijms241814247 crossref_primary_10_3389_fphar_2023_1304697 crossref_primary_10_1007_s00424_022_02726_3 crossref_primary_10_1371_journal_pgen_1011151 crossref_primary_10_3389_fimmu_2022_915580 crossref_primary_10_1055_a_1954_5605 crossref_primary_10_1016_j_lfs_2024_122895 crossref_primary_10_3390_biomedicines10050962 crossref_primary_10_3390_vaccines11040747 crossref_primary_10_3390_ph15020200 crossref_primary_10_1371_journal_pone_0280592 crossref_primary_10_3389_fcvm_2022_989428 crossref_primary_10_3390_biomedicines13030535 crossref_primary_10_1016_j_vph_2023_107250 crossref_primary_10_1038_s41598_023_38382_5 crossref_primary_10_3390_ijms24031923 crossref_primary_10_3390_molecules27238548 crossref_primary_10_3390_v13122493 crossref_primary_10_7759_cureus_20691 crossref_primary_10_1016_j_aanat_2025_152662 crossref_primary_10_1016_j_vaccine_2024_01_026 crossref_primary_10_3390_healthcare10040645 crossref_primary_10_1080_17460794_2025_2463243 crossref_primary_10_1038_s41598_022_20973_3 |
| Cites_doi | 10.1007/s00011-013-0633-0 10.1021/acschemneuro.0c00210 10.1210/en.2005-1318 10.1016/j.ccr.2012.11.010 10.1016/j.cell.2020.04.035 10.1161/HYPERTENSIONAHA.107.089599 10.1097/FJC.0000000000000960 10.1161/CIRCRESAHA.121.318902 10.1038/s42003-020-1088-9 10.1016/S0140-6736(20)30937-5 10.1038/s41467-020-18854-2 10.1001/jama.2020.11301 10.1152/ajplung.00223.2021 10.1038/s41433-020-0939-4 10.1038/s41598-020-80010-z 10.1152/ajpregu.00459.2002 10.1101/2021.01.18.21250041 10.1016/j.stem.2020.11.009 10.1002/path.1570 10.1016/j.regpep.2010.09.005 10.1016/j.mehy.2020.110112 10.1038/s41443-019-0163-6 10.1093/eurheartj/ehaa373 10.1161/hq0202.104001 10.1016/j.cell.2020.02.052 10.1056/NEJMoa2006923 10.1016/j.virusres.2009.01.005 10.1016/j.jaad.2015.05.026 10.1186/s12575-021-00153-9 10.1016/j.det.2010.03.011 10.1017/S1049023X20000837 10.1038/s41577-020-0343-0 10.1152/ajpheart.00396.2018 10.1006/meth.2001.1262 10.1093/cvr/cvp091 10.1038/s41467-020-19808-4 10.1210/endo-97-1-52 10.1093/infdis/jiaa528 10.1016/S2352-3026(20)30216-7 10.1093/cvr/cvaa230 10.1038/nature02145 10.1016/j.trsl.2020.04.007 10.1016/j.annonc.2020.04.479 10.1161/01.CIR.101.18.2149 10.1038/s41577-020-0348-8 10.1016/j.ejim.2020.04.037 10.1161/01.CIR.99.17.2317 10.1016/S0950-351X(98)80478-3 10.1016/S0140-6736(20)30858-8 10.1161/ATVBAHA.120.314860 10.1038/nri.2016.90 10.1016/j.jaad.2020.04.032 10.1161/01.HYP.0000259805.18468.8c 10.1186/s40249-020-00662-x 10.1146/annurev.med.45.1.361 10.1038/s41420-020-0276-1 10.3389/fmolb.2020.588618 10.3390/v13081555 10.21203/rs.3.rs-45837/v1 10.1186/s12916-020-01851-z 10.4330/wjc.v6.i5.227 10.1161/CIRCRESAHA.120.317134 10.7326/L20-0882 10.1016/j.nbd.2020.105131 10.1128/JVI.00794-21 10.1038/s41586-020-2700-3 10.1038/s41467-020-19741-6 10.3389/fcvm.2020.00143 |
| ContentType | Journal Article |
| Copyright | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021 |
| Copyright_xml | – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 by the authors. 2021 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7U9 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU COVID DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 7S9 L.6 5PM DOA |
| DOI | 10.3390/v13112209 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Coronavirus Research Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database ProQuest Biological Science Database (ProQuest) ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic AGRICOLA Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1999-4915 |
| ExternalDocumentID | oai_doaj_org_article_29ea2c7fc975437b97d2aac79e1dc36f PMC8617813 34835015 10_3390_v13112209 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | St Louis Missouri United States--US |
| GeographicLocations_xml | – name: St Louis Missouri – name: United States--US |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL122684 – fundername: NHLBI NIH HHS grantid: R01 HL115138 – fundername: Wellcome Trust – fundername: NHLBI NIH HHS grantid: R01 HL139672 – fundername: Intramural NIH HHS grantid: ZIA HL006262 – fundername: Intramural NIH HHS grantid: ZIA HL006263 – fundername: NCATS NIH HHS grantid: UL1 TR002240 – fundername: NHLBI NIH HHS grantid: R01 HL086694 |
| GroupedDBID | --- 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACUHS AFFHD AFKRA AFPKN AFZYC ALMA_UNASSIGNED_HOLDINGS BBNVY BENPR BHPHI BPHCQ BVXVI CCPQU CITATION DIK E3Z EBD ESX FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IHR ITC KQ8 LK8 M1P M48 M7P MODMG M~E O5R O5S OK1 PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO RPM TR2 TUS UKHRP 3V. ALIPV CGR CUY CVF ECM EIF ISR NPM 7U9 7XB 8FK AZQEC COVID DWQXO ESTFP GNUQQ H94 K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c502t-e29902e8cc0463f1ca9d0d8c9252f5866cbe9cbd539f9696982b9e4ee8b542293 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 40 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000725350500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1999-4915 |
| IngestDate | Fri Oct 03 12:52:23 EDT 2025 Tue Nov 04 01:58:01 EST 2025 Sun Nov 09 12:09:33 EST 2025 Fri Sep 05 08:37:15 EDT 2025 Tue Oct 07 06:23:06 EDT 2025 Wed Feb 19 02:24:51 EST 2025 Tue Nov 18 22:16:52 EST 2025 Sat Nov 29 07:12:08 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | COVID-19 E-selectin androgen angiotensin receptor blocker spironolactone endothelial injury |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c502t-e29902e8cc0463f1ca9d0d8c9252f5866cbe9cbd539f9696982b9e4ee8b542293 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-0153-3493 0000-0002-5660-5194 0000-0001-7613-2366 |
| OpenAccessLink | https://doaj.org/article/29ea2c7fc975437b97d2aac79e1dc36f |
| PMID | 34835015 |
| PQID | 2602249705 |
| PQPubID | 2032319 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_29ea2c7fc975437b97d2aac79e1dc36f pubmedcentral_primary_oai_pubmedcentral_nih_gov_8617813 proquest_miscellaneous_2636540779 proquest_miscellaneous_2604014349 proquest_journals_2602249705 pubmed_primary_34835015 crossref_citationtrail_10_3390_v13112209 crossref_primary_10_3390_v13112209 |
| PublicationCentury | 2000 |
| PublicationDate | 20211103 |
| PublicationDateYYYYMMDD | 2021-11-03 |
| PublicationDate_xml | – month: 11 year: 2021 text: 20211103 day: 3 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Viruses |
| PublicationTitleAlternate | Viruses |
| PublicationYear | 2021 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Zhang (ref_26) 2020; 126 Dosch (ref_35) 2009; 142 Gagliardi (ref_11) 2020; 6 Wambier (ref_2) 2020; 83 Okamura (ref_5) 2019; 93 Rathnayake (ref_70) 2010; 28 Montopoli (ref_15) 2020; 31 Varga (ref_17) 2020; 395 Lei (ref_33) 2021; 128 ref_51 McCrohon (ref_37) 1999; 99 Zuo (ref_66) 2021; 11 Singh (ref_50) 2007; 50 Klein (ref_10) 2016; 16 Hamming (ref_43) 2004; 203 Nakagawa (ref_49) 2003; 284 Goshua (ref_20) 2020; 7 Solopov (ref_30) 2021; 321 Hoffmann (ref_6) 2020; 181 Letarov (ref_32) 2021; 86 Aronova (ref_68) 2014; 6 Stanhewicz (ref_47) 2018; 315 Feldmann (ref_65) 2020; 395 Li (ref_4) 2003; 426 ref_22 Fox (ref_18) 2020; 173 Meyer (ref_29) 2021; 95 Nagashima (ref_21) 2020; 40 Wilcox (ref_23) 2020; 77 Zhu (ref_41) 1998; 12 Zelova (ref_44) 2013; 62 Mancia (ref_63) 2020; 382 Ridker (ref_64) 2000; 101 Takahashi (ref_7) 2020; 588 Scully (ref_8) 2020; 20 Bevilacqua (ref_52) 1994; 45 ref_72 Corvol (ref_42) 1975; 97 Verdecchia (ref_1) 2020; 76 Fosbol (ref_27) 2020; 324 Sama (ref_13) 2020; 41 Williams (ref_36) 2006; 147 Teuwen (ref_55) 2020; 20 Buzhdygan (ref_34) 2020; 146 Cadegiani (ref_67) 2020; 143 Zhong (ref_25) 2011; 166 Ziegler (ref_59) 2020; 181 Magro (ref_54) 2020; 220 Nienhold (ref_53) 2020; 11 Schmidt (ref_71) 2015; 73 Li (ref_12) 2020; 9 Shang (ref_28) 2021; 23 Bilinska (ref_58) 2020; 11 Yang (ref_3) 2007; 57 Peckham (ref_9) 2020; 11 Saponaro (ref_14) 2020; 7 Zhang (ref_31) 2020; 11 Nakagami (ref_38) 2002; 22 Sansone (ref_48) 2020; 32 Mascolo (ref_24) 2020; 7 ref_45 Guervilly (ref_19) 2020; 222 Sadoughi (ref_46) 2020; 35 Chapman (ref_69) 2007; 49 Cadegiani (ref_73) 2021; 13 Chakravarty (ref_60) 2020; 3 Sharma (ref_62) 2013; 23 Evans (ref_16) 2020; 116 Afar (ref_56) 2001; 61 Su (ref_39) 2009; 82 Ma (ref_57) 2020; 34 Samuel (ref_61) 2020; 27 Livak (ref_40) 2001; 25 |
| References_xml | – volume: 62 start-page: 641 year: 2013 ident: ref_44 article-title: TNF-alpha signalling and inflammation: Interactions between old acquaintances publication-title: Inflamm. Res. doi: 10.1007/s00011-013-0633-0 – volume: 11 start-page: 1555 year: 2020 ident: ref_58 article-title: Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age publication-title: ACS Chem. Neurosci. doi: 10.1021/acschemneuro.0c00210 – volume: 147 start-page: 2496 year: 2006 ident: ref_36 article-title: Protective effect of spironolactone on endothelial cell apoptosis publication-title: Endocrinology doi: 10.1210/en.2005-1318 – volume: 23 start-page: 35 year: 2013 ident: ref_62 article-title: The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.11.010 – volume: 181 start-page: 1016 year: 2020 ident: ref_59 article-title: SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues publication-title: Cell doi: 10.1016/j.cell.2020.04.035 – volume: 13 start-page: e13047 year: 2021 ident: ref_73 article-title: Early Antiandrogen Therapy with Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males with COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial—Biochemical) publication-title: Cureus – volume: 50 start-page: 123 year: 2007 ident: ref_50 article-title: Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.107.089599 – volume: 77 start-page: 323 year: 2020 ident: ref_23 article-title: Is spironolactone the preferred renin-angiotensin-aldosterone inhibitor for protection against COVID-19? publication-title: J. Cardiovasc. Pharmacol. doi: 10.1097/FJC.0000000000000960 – volume: 128 start-page: 1323 year: 2021 ident: ref_33 article-title: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.121.318902 – volume: 3 start-page: 374 year: 2020 ident: ref_60 article-title: Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer publication-title: Commun. Biol. doi: 10.1038/s42003-020-1088-9 – volume: 395 start-page: 1417 year: 2020 ident: ref_17 article-title: Endothelial cell infection and endotheliitis in COVID-19 publication-title: Lancet doi: 10.1016/S0140-6736(20)30937-5 – volume: 11 start-page: 5086 year: 2020 ident: ref_53 article-title: Two distinct immunopathological profiles in autopsy lungs of COVID-19 publication-title: Nat. Commun. doi: 10.1038/s41467-020-18854-2 – volume: 324 start-page: 168 year: 2020 ident: ref_27 article-title: Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use with COVID-19 Diagnosis and Mortality publication-title: JAMA doi: 10.1001/jama.2020.11301 – volume: 321 start-page: L477 year: 2021 ident: ref_30 article-title: The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Kappa18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. doi: 10.1152/ajplung.00223.2021 – volume: 34 start-page: 1212 year: 2020 ident: ref_57 article-title: Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea publication-title: Eye doi: 10.1038/s41433-020-0939-4 – volume: 11 start-page: 1580 year: 2021 ident: ref_66 article-title: Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients publication-title: Sci. Rep. doi: 10.1038/s41598-020-80010-z – volume: 284 start-page: R1055 year: 2003 ident: ref_49 article-title: Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00459.2002 – ident: ref_22 doi: 10.1101/2021.01.18.21250041 – volume: 27 start-page: 876 year: 2020 ident: ref_61 article-title: Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men publication-title: Cell Stem Cell doi: 10.1016/j.stem.2020.11.009 – volume: 203 start-page: 631 year: 2004 ident: ref_43 article-title: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis publication-title: J. Pathol. doi: 10.1002/path.1570 – volume: 166 start-page: 90 year: 2011 ident: ref_25 article-title: Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression publication-title: Regul. Pept. doi: 10.1016/j.regpep.2010.09.005 – volume: 143 start-page: 110112 year: 2020 ident: ref_67 article-title: Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS) publication-title: Med. Hypotheses doi: 10.1016/j.mehy.2020.110112 – volume: 32 start-page: 379 year: 2020 ident: ref_48 article-title: Effect of treatment with testosterone on endothelial function in hypogonadal men: A systematic review and meta-analysis publication-title: Int. J. Impot. Res. doi: 10.1038/s41443-019-0163-6 – volume: 41 start-page: 1810 year: 2020 ident: ref_13 article-title: Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehaa373 – volume: 22 start-page: 238 year: 2002 ident: ref_38 article-title: Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells publication-title: Arter. Thromb. Vasc. Biol. doi: 10.1161/hq0202.104001 – volume: 181 start-page: 271 year: 2020 ident: ref_6 article-title: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor publication-title: Cell doi: 10.1016/j.cell.2020.02.052 – volume: 382 start-page: 2431 year: 2020 ident: ref_63 article-title: Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2006923 – volume: 142 start-page: 19 year: 2009 ident: ref_35 article-title: SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-kappaB pathway in human monocyte macrophages in vitro publication-title: Virus. Res. doi: 10.1016/j.virusres.2009.01.005 – volume: 73 start-page: 672 year: 2015 ident: ref_71 article-title: Evidence-based approach to cutaneous hyperandrogenism in women publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2015.05.026 – volume: 57 start-page: 450 year: 2007 ident: ref_3 article-title: Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection publication-title: Comp. Med. – volume: 23 start-page: 16 year: 2021 ident: ref_28 article-title: Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System publication-title: Biol. Proced. Online doi: 10.1186/s12575-021-00153-9 – volume: 28 start-page: 611 year: 2010 ident: ref_70 article-title: Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss publication-title: Dermatol. Clin. doi: 10.1016/j.det.2010.03.011 – volume: 35 start-page: 438 year: 2020 ident: ref_46 article-title: An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes? publication-title: Prehosp. Disaster Med. doi: 10.1017/S1049023X20000837 – volume: 20 start-page: 389 year: 2020 ident: ref_55 article-title: COVID-19: The vasculature unleashed publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-020-0343-0 – volume: 315 start-page: H1569 year: 2018 ident: ref_47 article-title: Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00396.2018 – volume: 25 start-page: 402 year: 2001 ident: ref_40 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 82 start-page: 468 year: 2009 ident: ref_39 article-title: Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvp091 – volume: 61 start-page: 1686 year: 2001 ident: ref_56 article-title: Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia publication-title: Cancer Res. – volume: 11 start-page: 6013 year: 2020 ident: ref_31 article-title: SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity publication-title: Nat. Commun. doi: 10.1038/s41467-020-19808-4 – volume: 97 start-page: 52 year: 1975 ident: ref_42 article-title: Antiandrogenic effect of spirolactones: Mechanism of action publication-title: Endocrinology doi: 10.1210/endo-97-1-52 – volume: 222 start-page: 1789 year: 2020 ident: ref_19 article-title: Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID-19 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiaa528 – volume: 7 start-page: e575 year: 2020 ident: ref_20 article-title: Endotheliopathy in COVID-19-associated coagulopathy: Evidence from a single-centre, cross-sectional study publication-title: Lancet Haematol. doi: 10.1016/S2352-3026(20)30216-7 – volume: 116 start-page: 2177 year: 2020 ident: ref_16 article-title: Endothelial dysfunction in COVID-19: A position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvaa230 – volume: 426 start-page: 450 year: 2003 ident: ref_4 article-title: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus publication-title: Nature doi: 10.1038/nature02145 – volume: 220 start-page: 1 year: 2020 ident: ref_54 article-title: Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases publication-title: Transl. Res. doi: 10.1016/j.trsl.2020.04.007 – volume: 31 start-page: 1040 year: 2020 ident: ref_15 article-title: Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: A population-based study (N = 4532) publication-title: Ann. Oncol. doi: 10.1016/j.annonc.2020.04.479 – volume: 101 start-page: 2149 year: 2000 ident: ref_64 article-title: Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction publication-title: Circulation doi: 10.1161/01.CIR.101.18.2149 – volume: 20 start-page: 442 year: 2020 ident: ref_8 article-title: Considering how biological sex impacts immune responses and COVID-19 outcomes publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-020-0348-8 – volume: 76 start-page: 14 year: 2020 ident: ref_1 article-title: The pivotal link between ACE2 deficiency and SARS-CoV-2 infection publication-title: Eur. J. Intern. Med. doi: 10.1016/j.ejim.2020.04.037 – volume: 99 start-page: 2317 year: 1999 ident: ref_37 article-title: Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1 publication-title: Circulation doi: 10.1161/01.CIR.99.17.2317 – volume: 12 start-page: 83 year: 1998 ident: ref_41 article-title: Natural potent androgens: Lessons from human genetic models publication-title: Baillieres Clin. Endocrinol. Metab. doi: 10.1016/S0950-351X(98)80478-3 – volume: 395 start-page: 1407 year: 2020 ident: ref_65 article-title: Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed publication-title: Lancet doi: 10.1016/S0140-6736(20)30858-8 – volume: 40 start-page: 2404 year: 2020 ident: ref_21 article-title: Endothelial Dysfunction and Thrombosis in Patients with COVID-19-Brief Report publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.120.314860 – volume: 16 start-page: 626 year: 2016 ident: ref_10 article-title: Sex differences in immune responses publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.90 – volume: 83 start-page: 308 year: 2020 ident: ref_2 article-title: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2020.04.032 – volume: 49 start-page: 839 year: 2007 ident: ref_69 article-title: Effect of spironolactone on blood pressure in subjects with resistant hypertension publication-title: Hypertension doi: 10.1161/01.HYP.0000259805.18468.8c – volume: 9 start-page: 45 year: 2020 ident: ref_12 article-title: Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues publication-title: Infect. Dis. Poverty doi: 10.1186/s40249-020-00662-x – volume: 45 start-page: 361 year: 1994 ident: ref_52 article-title: Endothelial-leukocyte adhesion molecules in human disease publication-title: Annu. Rev. Med. doi: 10.1146/annurev.med.45.1.361 – volume: 6 start-page: 37 year: 2020 ident: ref_11 article-title: ACE2 expression and sex disparity in COVID-19 publication-title: Cell Death Discov. doi: 10.1038/s41420-020-0276-1 – volume: 7 start-page: 588618 year: 2020 ident: ref_14 article-title: ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives publication-title: Front. Mol. Biosci. doi: 10.3389/fmolb.2020.588618 – ident: ref_51 doi: 10.3390/v13081555 – ident: ref_72 doi: 10.21203/rs.3.rs-45837/v1 – ident: ref_45 doi: 10.1186/s12916-020-01851-z – volume: 6 start-page: 227 year: 2014 ident: ref_68 article-title: Management of hypertension in primary aldosteronism publication-title: World J. Cardiol. doi: 10.4330/wjc.v6.i5.227 – volume: 126 start-page: 1671 year: 2020 ident: ref_26 article-title: Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients with Hypertension Hospitalized with COVID-19 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.120.317134 – volume: 173 start-page: 1025 year: 2020 ident: ref_18 article-title: Cardiac Endotheliitis and Multisystem Inflammatory Syndrome After COVID-19 publication-title: Ann. Intern. Med. doi: 10.7326/L20-0882 – volume: 146 start-page: 105131 year: 2020 ident: ref_34 article-title: The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2020.105131 – volume: 95 start-page: e0079421 year: 2021 ident: ref_29 article-title: SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells publication-title: J. Virol. doi: 10.1128/JVI.00794-21 – volume: 93 start-page: e01815 year: 2019 ident: ref_5 article-title: TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection publication-title: J. Virol. – volume: 588 start-page: 315 year: 2020 ident: ref_7 article-title: Sex differences in immune responses that underlie COVID-19 disease outcomes publication-title: Nature doi: 10.1038/s41586-020-2700-3 – volume: 11 start-page: 6317 year: 2020 ident: ref_9 article-title: Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission publication-title: Nat. Commun. doi: 10.1038/s41467-020-19741-6 – volume: 7 start-page: 143 year: 2020 ident: ref_24 article-title: Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review publication-title: Front. Cardiovasc. Med. doi: 10.3389/fcvm.2020.00143 – volume: 86 start-page: 257 year: 2021 ident: ref_32 article-title: Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection publication-title: Biochemistry |
| SSID | ssj0066907 |
| Score | 2.4712915 |
| Snippet | Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 2209 |
| SubjectTerms | adhesion androgen Androgens Angiotensin Receptor Antagonists - pharmacology angiotensin receptor blocker antagonism cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - blood Cells, Cultured Coronaviruses COVID-19 COVID-19 - pathology COVID-19 - physiopathology COVID-19 - virology COVID-19 infection death Dihydrotestosterone Dihydrotestosterone - pharmacology disease severity Disease transmission E-selectin Endothelial cells endothelial injury Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Female Fibrin Gender differences Heart failure Humans Infections Inflammation Intercellular adhesion molecule 1 Male mineralocorticoid receptors Monocytes Pandemics Proteins SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Sex Characteristics Spike Glycoprotein, Coronavirus - physiology Spike protein spironolactone Spironolactone - pharmacology therapeutics tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology Tumor necrosis factor-TNF Tumor necrosis factor-α Valsartan - pharmacology Vascular cell adhesion molecule 1 vascular cell adhesion molecules Viral infections Women |
| SummonAdditionalLinks | – databaseName: ProQuest Publicly Available Content Database dbid: PIMPY link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFLagA4kLvweFgQziwMVq4sSxfUJlbKKHThUFNE6R4x8ssDml7Sb1_-EPxc9Jy4qmnTg2-ZI6yufn9_Kev4fQG-dskRtrCKuKEKCIVBHhEka4U4kwSrg8VbHZBD86EsfHctJtj150ZZVrmxgNdav2DHXbwQgPTKPhi_kgeOFh7ZE8Ye9mvwj0kIJca9dQ4ybaAeEt2kM7k9F48m1tmQuIBFt1oSyE-oMLkJqhFGoRL61JUbr_Kn_z37LJS-vQ4b3_-wT30d3OH8XDlkAP0A3rH6LbbYfK1SP0ezr8NCX7zVdC8XRW_7R4AsIOtcfTlIxjmw9r8IE3sJHrNHAZj_yP8Jqw8gagZORd4NxZzOXj6Nni0QIPoY7dBe8XVyv8oT5ZGbhr8ENBtqHxtrs8qku1oHEd5bGbECyHkTa1wUMPCTVfL84eoy-HB5_3P5KusQPRLKFLYmENpFZoDXplLtVKmsQILSmjjomi0JWVujIskw7Ue6SglbS5taJiOQ0Oyi7q-TCYpwhXmeVVYlgqAkAlTDEWfjgGqenga2V99Hb9akvdqZ5D843TMkQ_wIJyw4I-er2Bzlqpj6tA74EfGwCoc8cDzfx72U32kkqrqOZOS87yjFeSG6qU5tKmRmeF66O9NUPKzmQsyr-E6KNXm9NhskMGR3nbnEdMDoKMubwOkxWgqsgD5klL2M1os1xAIjn8A9-i8tbjbJ_x9UkUHRewlzTNnl0_9OfoDoWiH_junu2h3nJ-bl-gW_piWS_mL7v5-AcLgkqg priority: 102 providerName: ProQuest |
| Title | SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34835015 https://www.proquest.com/docview/2602249705 https://www.proquest.com/docview/2604014349 https://www.proquest.com/docview/2636540779 https://pubmed.ncbi.nlm.nih.gov/PMC8617813 https://doaj.org/article/29ea2c7fc975437b97d2aac79e1dc36f |
| Volume | 13 |
| WOSCitedRecordID | wos000725350500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1999-4915 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066907 issn: 1999-4915 databaseCode: DOA dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1999-4915 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066907 issn: 1999-4915 databaseCode: M~E dateStart: 20090101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database (ProQuest) customDbUrl: eissn: 1999-4915 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066907 issn: 1999-4915 databaseCode: M7P dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1999-4915 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066907 issn: 1999-4915 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1999-4915 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066907 issn: 1999-4915 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1999-4915 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066907 issn: 1999-4915 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdggMQL4pvCqAzigZdoiRPH9mM3OtGHVtUKaDxFjj-0wOZOazep_w9_KHdOWrVoghdeIiX-JTnH5_gud_kdIR-8d2VhnU14XYKDIjOdSJ_yRHidSqulLzIdi02IyUSenqrpVqkvzAlr6YHbB3fAlNPMCG-U4EUuaiUs09oI5TJr8tLj2zcVau1Mte_gEn2-lkcoB6f-4AZJZRjDrMOt1SeS9N9mWf6ZILm14hw_Jo86U5EOWhGfkDsuPCUP2uKRq2fk12xwMkuO5t8SRmeXzU9Hp8i50AQ6y5JxrMDhLB0Gi_9YnYOa0VH4AU-Q6mARmoyCB3W4iGF2Go1OOlrQAaaYezBMab2in5qzlcWrgomIjArz4LrTI_FTCxo3kbl6Dn4sSDpvLB0EjHWFZnHxnHw9Hn45-px0NRcSw1O2TBwuT8xJY5BKzGdGK5taaRTjzHNZlqZ2ytSW58ojsY6SrFaucE7WvGBgO7wgewGEeUVonTtRp5ZnEgA65Zpz2PEco8ZgBuU98nE9FpXpCMmxLsZ5BY4JDlu1GbYeeb-BXrYsHLeBDnFANwAkzo4HQJ2qTp2qf6lTj-yv1aHqZvOiAp8PLB0lUt4j7zbNMA8xuKKDm19HTIFciYX6GyYvkfBQAOZlq2EbafNCYowX7iB2dG-nO7stoTmLfOASf_PM8tf_o_9vyEOGWTv44TzfJ3vLq2v3ltw3N8tmcdUnd8WpiFvZJ_cOh5PpST9OvD7mzE7h2HQ0nn7_DSspNrk |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBQQX3o9AgQWBxMWqvfZ6dw8IhT7UqE1UkYJyc-19UEO7DklalP_Dmd_IztoxDap664Fj4i_JxpmZncnMfh9Cb4zRaaK0CmiRugKFR3nATUgDZvKQq5ybJMq92AQbDPhoJPZX0O_FWRgYq1zERB-oVSXhP_J1l3e73UawkH4Y_whANQq6qwsJjdosdvX8pyvZpu97m-73fUvI9tbBxk7QqAoEkoZkFmgIwERzKYEsy0QyFypUXApCiaE8TWWhhSwUjYUB6hjBSSF0ojUvaEIIkC-5kH_NxXEGigls1BZ4KVSaNXtRHItw_QyobAiBWcdze56XBrgon_13LPPcPrd953-7Q3fR7Sajxt3aBe6hFW3voxu1xub8Afo17H4aBhvVl4Dg4bj8rvE-UFOUFg-joO-FSrTCW1bBUbRj5424Z785Q8O5VQANetY4rznx0wjY5-a4N8VdmMQ3Ln_HxRxvlkdzBe_qMmkgnqisbl7u-bFqUL_0BN-VK_fdSqtS4a6FlqAtpycP0ecruUWP0Kp1i3mCcBFrVoSKRtwB8pDmlLoHhkJz3WWLcQe9WxhPJhvedpAPOc5c_QZ2lrV21kGvW-i4Jiu5CPQRLLAFAL-4f6KafM2acJURoXMimZGC0SRmhWCK5LlkQkdKxqnpoLWFDWZN0Jtmfw2wg161l124gh5UbnV16jEJUEom4jJMnAIvJHOYx7VLtKuNEw6tcPcJbMlZlr7O8hVbHnnadA6nYaP46eVLf4lu7hz097K93mD3GbpFYIQJugjxGlqdTU71c3Rdns3K6eSF932MDq_alf4AIpSaLQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLamcREv3C-FAQaBxEvUxIkT-wGhsq6iGqsqCmhvwfGFBTantN1Q_w-_gl-Hj5OUFU172wOPib8kjnPO8XHO8XcQemGMThOlVUCL1C1QWCQCZkIaZEaETAlmkkj4YhPZaMT29_l4A_1u98JAWmVrE72hVpWEf-Rd53e72YZnIe2aJi1i3B-8mf4IoIIURFrbchq1iOzq5U-3fJu_Hvbdt35JyGDn4_a7oKkwEEgakkWgwRgTzaQE4iwTScFVqJjkhBJDWZrKQnNZKBpzAzQynJGC60RrVtCEECBicub_UpakYeLTBsftLJDCqrNmMopjHnZPgNaGEMh7PDX_-TIBZ_m2_6ZonprzBjf-59G6ia43njbu1apxC21oextdqWtvLu-gX5Peh0mwXX0OCJ5My-8aj4GyorR4EgV7voCJVnjHKtiidui0FA_tNyeAWFgF0GBojdOmI5-lgL3Pjodz3IMMfeP8elwscb88WCq4q_OwgZCisrq53PNm1aC90hN_V7KCnlalwj0LoUJbzo_uok8XMkT30KZ1nXmAcBHrrAgVjZgDiJAKSt2BoRB0d15k3EGvWkHKZcPnDmVFDnO3rgOZy1cy10HPV9BpTWJyFugtSOMKALzj_kQ1-5o3ZiwnXAsiMyN5RpM4K3imiBAy4zpSMk5NB2218pg3xnCe_xXGDnq2anZmDGJTwurq2GMSoJpM-HmYOAW-yMxh7tfqseptnDAIkbsnZGuKs_Y66y22PPB06gx2yUbxw_O7_hRddRqUvx-Odh-hawQymyC4EG-hzcXsWD9Gl-XJopzPnngzgNGXi9akP1gNowQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SARS-CoV-2+Spike+Protein+S1-Mediated+Endothelial+Injury+and+Pro-Inflammatory+State+Is+Amplified+by+Dihydrotestosterone+and+Prevented+by+Mineralocorticoid+Antagonism&rft.jtitle=Viruses&rft.au=Nitin+Kumar&rft.au=Yu+Zuo&rft.au=Srilakshmi+Yalavarthi&rft.au=Kristina+L.+Hunker&rft.date=2021-11-03&rft.pub=MDPI+AG&rft.eissn=1999-4915&rft.volume=13&rft.issue=11&rft.spage=2209&rft_id=info:doi/10.3390%2Fv13112209&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_29ea2c7fc975437b97d2aac79e1dc36f |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1999-4915&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1999-4915&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1999-4915&client=summon |