Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence

Sarcomas are still unsolved therapeutic challenges. Cancer stem cells are believed to contribute to sarcoma development, but lack of specific markers prevents their characterization and targeting. Here, we show that calpain-6 expression is associated with cancer stem cell features. In mouse models o...

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Bibliographic Details

Published in:	JCI insight Vol. 3; no. 17
Main Authors:	Andrique, Caroline, Morardet, Laetitia, Linares, Laetitia K., Cissé, Madi Y., Merle, Candice, Chibon, Frédéric, Provot, Sylvain, Haÿ, Eric, Ea, Hang-Korng, Cohen-Solal, Martine, Modrowski, Dominique
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 06.09.2018
Subjects:	Cancer Human health and pathology Life Sciences Oncology Autophagy Oncogenes Cellular senescence
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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