High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Individual reports suggest that the central nervous system (CNS) contains multiple immune cell types with diverse roles in tissue homeostasis, immune defense, and neurological diseases. It has been challenging to map leukocytes across the entire brain, and in particular in pathology, where phenotypi...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 48; H. 2; S. 380
Hauptverfasser:	Mrdjen, Dunja, Pavlovic, Anto, Hartmann, Felix J, Schreiner, Bettina, Utz, Sebastian G, Leung, Brian P, Lelios, Iva, Heppner, Frank L, Kipnis, Jonathan, Merkler, Doron, Greter, Melanie, Becher, Burkhard
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.02.2018
Schlagworte:	high-dimensional macrophages experimental autoimmune encephalomyelitis Alzheimer’s disease multiple sclerosis neurodegeneration aging mass cytometry microglia central nervous system
ISSN:	1097-4180, 1097-4180
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