TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are associated with Alzheimer's disease (AD). Starting from an unbiased protein microarray screen, we identified a set of lipoprotein particles (including LDL) and apolipoproteins (including CLU/APOJ and APOE)...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 91; H. 2; S. 328 - 340
Hauptverfasser:	Yeh, Felix L, Wang, Yuanyuan, Tom, Irene, Gonzalez, Lino C, Sheng, Morgan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.07.2016
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Apolipoproteins - metabolism Brain - metabolism Cell Line Humans Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Microglia - metabolism Protein Binding Receptors, Immunologic - genetics Receptors, Immunologic - metabolism
ISSN:	1097-4199
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