Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts of glucose producing large volumes of lactate even in the presence of oxygen, this process is known as "Warburg eff...

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Vydané v:	Frontiers in oncology Ročník 9; s. 1143
Hlavní autori:	de la Cruz-López, Karen G., Castro-Muñoz, Leonardo Josué, Reyes-Hernández, Diego O., García-Carrancá, Alejandro, Manzo-Merino, Joaquín
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Frontiers Media S.A 01.11.2019
Predmet:	acidification immune response lactate Oncology therapy tumor microenvironment (TME)
ISSN:	2234-943X, 2234-943X
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