Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts of glucose producing large volumes of lactate even in the presence of oxygen, this process is known as "Warburg eff...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 9; p. 1143
Main Authors:	de la Cruz-López, Karen G., Castro-Muñoz, Leonardo Josué, Reyes-Hernández, Diego O., García-Carrancá, Alejandro, Manzo-Merino, Joaquín
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 01.11.2019
Subjects:	acidification immune response lactate Oncology therapy tumor microenvironment (TME)
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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