MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma

Background/Aims: Classical Hodgkin lymphoma (cHL) is among the most frequent lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells that escaped from apoptosis. MicroRNAs (miRNAs) play important roles in B-cell maturation and aberrant expression of miRNAs contributes...

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Veröffentlicht in:	Cellular physiology and biochemistry Jg. 49; H. 1; S. 144 - 159
Hauptverfasser:	Yuan, Ye, Niu, Fubiao, Nolte, Ilja M., Koerts, Jasper, de Jong, Debora, Rutgers, Bea, Osinga, Jan, Azkanaz, Maria, Terpstra, Martijn, Bystrykh, Leonid, Diepstra, Arjan, Visser, Lydia, Dzikiewicz-Krawczyk, Agnieszka, Kok, Klaas, Kluiver, Joost , van den Berg, Anke
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Basel, Switzerland S. Karger AG 01.09.2018 Cell Physiol Biochem Press GmbH & Co KG
Schlagworte:	3' Untranslated Regions Antagomirs - metabolism Apoptosis Breast cancer BTG2 Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - genetics Classical Hodgkin lymphoma (cHL) Deoxyribonucleic acid DNA Gene expression HEK293 Cells High-Throughput Nucleotide Sequencing High-throughput screen Hodgkin Disease - metabolism Hodgkin Disease - pathology Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Infections Lymphoma MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-21-5p Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncogenes - genetics Original Paper PELI1 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism United States > US High-throughput screen PELI1 Classical Hodgkin lymphoma (cHL) BTG2 miR-21-5p Apoptosis
ISSN:	1015-8987, 1421-9778, 1421-9778
Online-Zugang:	Volltext
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