Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective

Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational powe...

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Published in:Frontiers in physiology Vol. 14; p. 1132165
Main Authors: Ismaili, Djemail, Schulz, Carl, Horváth, András, Koivumäki, Jussi T., Mika, Delphine, Hansen, Arne, Eschenhagen, Thomas, Christ, Torsten
Format: Journal Article
Language:English
Published: Switzerland Frontiers 16.02.2023
Frontiers Media S.A
Subjects:
action potentials
computer modelling and simulation
hESC-CM
hiPSC-CM
human cardiomyocytes
ion currents
Life Sciences
Physiology
human cardiomyocytes
computer modelling and simulation
hiPSC-CM
action potentials
automated patch clamp
ion currents
hESC-CM
ISSN:1664-042X, 1664-042X
Online Access:Get full text
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Summary:Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.
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Yael Yaniv, Technion Israel Institute of Technology, Israel
Edited by: Yoram Etzion, Ben-Gurion University of the Negev, Israel
This article was submitted to Cardiac Electrophysiology, a section of the journal Frontiers in Physiology
Reviewed by: Antonio Carlos Campos De Carvalho, Federal University of Rio De Janeiro, Brazil
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2023.1132165