Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Current opinion in neurobiology Ročník 15; číslo 3; s. 370 - 378
Hlavní autoři: Suh, Byung-Chang, Hille, Bertil
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.06.2005
Témata:
Cell Membrane - chemistry
Cell Membrane - physiology
Ion Channels - physiology
Phosphatidylinositol 4,5-Diphosphate - chemistry
Phosphatidylinositol 4,5-Diphosphate - metabolism
ISSN:0959-4388, 1873-6882
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2005.05.005