A Genomewide Association Study of Nicotine and Alcohol Dependence in Australian and Dutch Populations

Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these ad...

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Published in:Twin research and human genetics Vol. 13; no. 1; pp. 10 - 29
Main Authors: Lind, Penelope A, Macgregor, Stuart, Vink, Jacqueline M, Pergadia, Michele L, Hansell, Narelle K, de Moor, Marleen H. M, Smit, August B, Hottenga, Jouke-Jan, Richter, Melinda M, Heath, Andrew C, Martin, Nicholas G, Willemsen, Gonneke, de Geus, Eco J. C, Vogelzangs, Nicole, Penninx, Brenda W, Whitfield, John B, Montgomery, Grant W, Boomsma, Dorret I, Madden, Pamela A. F
Format: Journal Article
Language:English
Published: England 01.02.2010
Subjects:
Adult
Aged
Alcoholism
Alcoholism - epidemiology
Alcoholism - genetics
Australia - epidemiology
Case-Control Studies
Comorbidity
DEAD-box RNA Helicases - genetics
Diseases in Twins - epidemiology
Diseases in Twins - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
GTPase-Activating Proteins - genetics
Humans
Male
Middle Aged
Netherlands - epidemiology
Polymorphism, Single Nucleotide
Protein Serine-Threonine Kinases - genetics
Proto-Oncogene Proteins - genetics
Registries
rhoA GTP-Binding Protein
Statistics
Substance abuse
Tobacco Use Disorder - epidemiology
Tobacco Use Disorder - genetics
Twins
Australia
Netherlands
ISSN:1832-4274
Online Access:Get full text
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Summary:Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these addictions, we first conducted a pooling-based genomewide association study (GWAS) in an Australian population, using Illumina Infinium 1M arrays. Allele frequency differences were compared between pooled DNA from case and control groups for: (1) AD, 1224 cases and 1162 controls; (2) ND, 1273 cases and 1113 controls; and (3) comorbid AD and ND, 599 cases and 488 controls. Secondly, we carried out a GWAS in independent samples from the Netherlands for AD and for ND. Thirdly, we performed a meta-analysis of the 10,000 most significant AD- and ND-related SNPs from the Australian and Dutch samples.
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Twin Research and Human Genetics, Vol. 13, No. 1, Feb 2010: 10-29
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These authors contributed equally to the work reported
ISSN:1832-4274
DOI:10.1375/twin.13.1.10