A Genomewide Association Study of Nicotine and Alcohol Dependence in Australian and Dutch Populations

Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these ad...

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Vydáno v:	Twin research and human genetics Ročník 13; číslo 1; s. 10 - 29
Hlavní autoři:	Lind, Penelope A, Macgregor, Stuart, Vink, Jacqueline M, Pergadia, Michele L, Hansell, Narelle K, de Moor, Marleen H. M, Smit, August B, Hottenga, Jouke-Jan, Richter, Melinda M, Heath, Andrew C, Martin, Nicholas G, Willemsen, Gonneke, de Geus, Eco J. C, Vogelzangs, Nicole, Penninx, Brenda W, Whitfield, John B, Montgomery, Grant W, Boomsma, Dorret I, Madden, Pamela A. F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.02.2010
Témata:	Adult Aged Alcoholism Alcoholism - epidemiology Alcoholism - genetics Australia - epidemiology Case-Control Studies Comorbidity DEAD-box RNA Helicases - genetics Diseases in Twins - epidemiology Diseases in Twins - genetics Female Genetic Predisposition to Disease Genome-Wide Association Study GTPase-Activating Proteins - genetics Humans Male Middle Aged Netherlands - epidemiology Polymorphism, Single Nucleotide Protein Serine-Threonine Kinases - genetics Proto-Oncogene Proteins - genetics Registries rhoA GTP-Binding Protein Statistics Substance abuse Tobacco Use Disorder - epidemiology Tobacco Use Disorder - genetics Twins Australia Netherlands
ISSN:	1832-4274
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Shrnutí:	Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these addictions, we first conducted a pooling-based genomewide association study (GWAS) in an Australian population, using Illumina Infinium 1M arrays. Allele frequency differences were compared between pooled DNA from case and control groups for: (1) AD, 1224 cases and 1162 controls; (2) ND, 1273 cases and 1113 controls; and (3) comorbid AD and ND, 599 cases and 488 controls. Secondly, we carried out a GWAS in independent samples from the Netherlands for AD and for ND. Thirdly, we performed a meta-analysis of the 10,000 most significant AD- and ND-related SNPs from the Australian and Dutch samples.
Bibliografie:	TRHG_c.jpg Twin Research and Human Genetics, Vol. 13, No. 1, Feb 2010: 10-29 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to the work reported
ISSN:	1832-4274
DOI:	10.1375/twin.13.1.10