Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial

Escherichia coli infections are increasing worldwide in community and hospital settings. The E coli O-antigen is a promising vaccine target. We aimed to assess the safety and immunogenicity of a bioconjugate vaccine containing the O-antigens of four E coli serotypes (ExPEC4V). In this multicentre ph...

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Bibliographic Details
Published in:	The Lancet infectious diseases Vol. 17; no. 5; pp. 528 - 537
Main Authors:	Huttner, Angela, Hatz, Christoph, van den Dobbelsteen, Germie, Abbanat, Darren, Hornacek, Alena, Frölich, Rahel, Dreyer, Anita M, Martin, Patricia, Davies, Todd, Fae, Kellen, van den Nieuwenhof, Ingrid, Thoelen, Stefan, de Vallière, Serge, Kuhn, Anette, Bernasconi, Enos, Viereck, Volker, Kavvadias, Tilemachos, Kling, Kerstin, Ryu, Gloria, Hülder, Tanja, Gröger, Sabine, Scheiner, David, Alaimo, Cristina, Harbarth, Stephan, Poolman, Jan, Fonck, Veronica Gambillara
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.05.2017 Elsevier Limited
Subjects:	Adult Aged Antibodies Antigens Bacteria E coli Epidemiology Escherichia coli Escherichia coli Vaccines - administration & dosage Escherichia coli Vaccines - therapeutic use Extraintestinal Pathogenic Escherichia coli - isolation & purification Female Humans Immune response Immunogenicity Immunogenicity, Vaccine Incidence Infections Infectious Disease Infectious diseases Injection Investigations Middle Aged Pathogens Safety Single-Blind Method Treatment Outcome Urinary tract infections Urinary Tract Infections - prevention & control Vaccination - methods Vaccines United States > US
ISSN:	1473-3099, 1474-4457, 1474-4457
Online Access:	Get full text
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