Achieving a cure for HIV infection: do we have reasons to be optimistic?

The introduction of highly active antiretroviral therapy (HAART) in 1996 has transformed a lethal disease to a chronic pathology with a dramatic decrease in mortality and morbidity of AIDS-related symptoms in infected patients. However, HAART has not allowed the cure of HIV infection, the main obsta...

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Vydané v:Journal of antimicrobial chemotherapy Ročník 67; číslo 5; s. 1063
Hlavní autori: Le Douce, Valentin, Janossy, Andrea, Hallay, Houda, Ali, Sultan, Riclet, Raphael, Rohr, Olivier, Schwartz, Christian
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.05.2012
Predmet:
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - pharmacology
Antiretroviral Therapy, Highly Active - methods
HIV - drug effects
HIV - pathogenicity
HIV Infections - drug therapy
Humans
Treatment Outcome
ISSN:1460-2091, 1460-2091
On-line prístup:Zistit podrobnosti o prístupe
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Popis
Shrnutí:The introduction of highly active antiretroviral therapy (HAART) in 1996 has transformed a lethal disease to a chronic pathology with a dramatic decrease in mortality and morbidity of AIDS-related symptoms in infected patients. However, HAART has not allowed the cure of HIV infection, the main obstacle to HIV eradication being the existence of quiescent reservoirs. Several other problems have been encountered with HAART (such as side effects, adherence to medication, emergence of resistance and cost of treatment), and these motivate the search for new ways to treat these patients. Recent advances hold promise for the ultimate cure of HIV infection, which is the topic of this review. Besides these new strategies aiming to eliminate the virus, efforts must be made to improve current HAART. We believe that the cure of HIV infection will not be attained in the short term and that a strategy based on purging the reservoirs has to be associated with an aggressive HAART strategy.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1460-2091
1460-2091
DOI:10.1093/jac/dkr599