Genomic features of in vitro selected mutants of Escherichia coli with decreased susceptibility to tigecycline

•Tigecycline (TGC) is a last resort agent for treatment of serious infections caused by XDR bacteria.•In vitro developed TGC resistant isolates of Escherichia coli were studied by whole-genome sequencing.•Alterations in MarR, Lon, AcrB, WaaQ, EptB, RpsI, and RpoB proteins were identified.•Alteration...

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Veröffentlicht in:	Journal of Global Antimicrobial Resistance Jg. 31; S. 32 - 37
Hauptverfasser:	Haeili, Mehri, Shoghi, Yalda, Moghimi, Mohaddeseh, Ghodousi, Arash, Omrani, Maryam, Cirillo, Daniela Maria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.12.2022 Elsevier
Schlagworte:	Efflux pumps Escherichia coli Escherichia coli - genetics Fitness cost Genomics Infectious Disease Lipopolysaccharides LPS inner core biosynthesis pathway Microbial Sensitivity Tests Ribosomal protein Tigecycline - pharmacology Tigecycline resistance Tigecycline resistance Efflux pumps Fitness cost LPS inner core biosynthesis pathway Ribosomal protein Escherichia coli ribosomal protein fitness cost efflux pumps
ISSN:	2213-7165, 2213-7173, 2213-7165, 2213-7173
Online-Zugang:	Volltext
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