TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels

Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechani...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 105; H. 2; S. 310
Hauptverfasser:	Jia, Yanyan, Zhao, Yimeng, Kusakizako, Tsukasa, Wang, Yao, Pan, Chengfang, Zhang, Yuwei, Nureki, Osamu, Hattori, Motoyuki, Yan, Zhiqiang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.01.2020
Schlagworte:	Animals Animals, Genetically Modified Cell Line Female Ion Channels - metabolism Liposomes - metabolism Mechanotransduction, Cellular - physiology Melopsittacus Membrane Proteins - biosynthesis Membrane Proteins - genetics Membrane Proteins - physiology Mutation Spodoptera Turtles TMC1 auditory transduction ion channel mechanotransduction hair cell TMC2
ISSN:	1097-4199, 1097-4199
Online-Zugang:	Weitere Angaben
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