Clinically Important Phleboviruses and Their Detection in Human Samples

The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here,...

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Bibliographic Details
Published in:Viruses Vol. 13; no. 8; p. 1500
Main Authors: Lambert, Amy J., Hughes, Holly R.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 30.07.2021
MDPI
Subjects:
Acids
Animals
Antibodies
Antibodies, Viral - blood
Antigens
Epidemics
Fever
Genetic diversity
Genetic Variation
Genomes
human diseases
human samples
Humans
Illnesses
Infections
Pathogens
Phenuiviridae
Phlebotomus Fever - diagnosis
Phlebotomus Fever - immunology
Phlebotomus Fever - transmission
Phlebotomus Fever - virology
Phlebovirus - classification
Phlebovirus - genetics
Phlebovirus - immunology
Phlebovirus - pathogenicity
phleboviruses
Phylogeny
Psychodidae - virology
Serology
viral detection
Viral infections
Viremia
Viruses
Brazil
phleboviruses
human samples
viral detection
ISSN:1999-4915, 1999-4915
Online Access:Get full text
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Summary:The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here, we seek to inform the detection of human phlebovirus infections by providing a brief introduction to clinically relevant phleboviruses, as well as key targets and approaches for their detection. Given the diversity of pathogens within the genus, this report focuses on diagnostic attributes that are generally shared among these agents and should be used as a complement to, rather than a replacement of, more detailed discussions on the detection of phleboviruses at the individual virus level.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v13081500