Clinically Important Phleboviruses and Their Detection in Human Samples

The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here,...

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Veröffentlicht in:	Viruses Jg. 13; H. 8; S. 1500
Hauptverfasser:	Lambert, Amy J., Hughes, Holly R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 30.07.2021 MDPI
Schlagworte:	Acids Animals Antibodies Antibodies, Viral - blood Antigens Epidemics Fever Genetic diversity Genetic Variation Genomes human diseases human samples Humans Illnesses Infections Pathogens Phenuiviridae Phlebotomus Fever - diagnosis Phlebotomus Fever - immunology Phlebotomus Fever - transmission Phlebotomus Fever - virology Phlebovirus - classification Phlebovirus - genetics Phlebovirus - immunology Phlebovirus - pathogenicity phleboviruses Phylogeny Psychodidae - virology Serology viral detection Viral infections Viremia Viruses Brazil phleboviruses human samples viral detection
ISSN:	1999-4915, 1999-4915
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Abstract	The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here, we seek to inform the detection of human phlebovirus infections by providing a brief introduction to clinically relevant phleboviruses, as well as key targets and approaches for their detection. Given the diversity of pathogens within the genus, this report focuses on diagnostic attributes that are generally shared among these agents and should be used as a complement to, rather than a replacement of, more detailed discussions on the detection of phleboviruses at the individual virus level.
AbstractList	The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here, we seek to inform the detection of human phlebovirus infections by providing a brief introduction to clinically relevant phleboviruses, as well as key targets and approaches for their detection. Given the diversity of pathogens within the genus, this report focuses on diagnostic attributes that are generally shared among these agents and should be used as a complement to, rather than a replacement of, more detailed discussions on the detection of phleboviruses at the individual virus level. The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here, we seek to inform the detection of human phlebovirus infections by providing a brief introduction to clinically relevant phleboviruses, as well as key targets and approaches for their detection. Given the diversity of pathogens within the genus, this report focuses on diagnostic attributes that are generally shared among these agents and should be used as a complement to, rather than a replacement of, more detailed discussions on the detection of phleboviruses at the individual virus level.The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here, we seek to inform the detection of human phlebovirus infections by providing a brief introduction to clinically relevant phleboviruses, as well as key targets and approaches for their detection. Given the diversity of pathogens within the genus, this report focuses on diagnostic attributes that are generally shared among these agents and should be used as a complement to, rather than a replacement of, more detailed discussions on the detection of phleboviruses at the individual virus level. The detection of phleboviruses (family: ) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awareness among some clinicians and laboratorians. Here, we seek to inform the detection of human phlebovirus infections by providing a brief introduction to clinically relevant phleboviruses, as well as key targets and approaches for their detection. Given the diversity of pathogens within the genus, this report focuses on diagnostic attributes that are generally shared among these agents and should be used as a complement to, rather than a replacement of, more detailed discussions on the detection of phleboviruses at the individual virus level.
Author	Lambert, Amy J. Hughes, Holly R.
AuthorAffiliation	2 Arbovirus Diagnostic and Reference Team, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road-Foothills Research Campus, Fort Collins, CO 80521, USA 1 Arbovirus Reference and Reagent Laboratory, WHO Collaborating Center, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road-Foothills Research Campus, Fort Collins, CO 80521, USA; ltr8@cdc.gov
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Cites_doi	10.1111/j.1863-2378.2011.01436.x 10.1002/jmv.10465 10.3201/eid1605.100170 10.3390/v13050918 10.4269/ajtmh.19-0717 10.1093/cid/ciab175 10.3201/eid1609.100505 10.1186/s13071-020-04110-5 10.3201/eid2610.191837 10.3390/v11050469 10.3201/eid1502.080722 10.1016/B978-0-12-801238-3.02660-X 10.1128/JVI.02275-10 10.1007/s12250-019-00096-2 10.1016/j.jcv.2007.10.001 10.3201/eid1111.050869 10.1099/vir.0.051359-0 10.4269/ajtmh.2010.09-0697 10.3201/eid2610.191374 10.3390/v13020209 10.1016/j.jcv.2010.05.011 10.1128/JCM.00182-09 10.3201/eid2412.171626 10.3201/eid2504.180750 10.1128/JVI.03027-14 10.1186/s13071-016-1488-3 10.1002/path.1700340418 10.1186/s13071-018-2668-0 10.4269/ajtmh.1982.31.149 10.4269/ajtmh.1976.25.456 10.4269/ajtmh.14-0299
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Copyright	2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021
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SubjectTerms	Acids Animals Antibodies Antibodies, Viral - blood Antigens Epidemics Fever Genetic diversity Genetic Variation Genomes human diseases human samples Humans Illnesses Infections Pathogens Phenuiviridae Phlebotomus Fever - diagnosis Phlebotomus Fever - immunology Phlebotomus Fever - transmission Phlebotomus Fever - virology Phlebovirus - classification Phlebovirus - genetics Phlebovirus - immunology Phlebovirus - pathogenicity phleboviruses Phylogeny Psychodidae - virology Serology viral detection Viral infections Viremia Viruses
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Title	Clinically Important Phleboviruses and Their Detection in Human Samples
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