Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes

Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD), which is believed to interfere with the host...

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Vydané v:	IUCrJ Ročník 7; číslo 5; s. 814 - 824
Hlavní autori:	Michalska, Karolina, Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I., Stols, Lucy, Endres, Michael, Joachimiak, Andrzej
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England International Union of Crystallography 01.09.2020
Predmet:	ADP-ribose phosphatase domain ADP-ribosylation ADRP BASIC BIOLOGICAL SCIENCES Coordination compounds Coronaviruses COVID-19 Crystal structure Enzymes Health aspects Homology Ligands Mac1 macrodomain Monosaccharides Nsp3 Phosphatase Phosphatases Proteins Research Papers Ribose RNA SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases Water chemistry COVID-19 SARS-CoV-2 Mac1 crystal structure macrodomain ADP-ribose phosphatase domain Nsp3 ADP-ribosylation ADRP
ISSN:	2052-2525, 2052-2525
On-line prístup:	Získať plný text
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