Engineering and expressing circular RNAs via tRNA splicing

Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here,...

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Bibliographic Details
Published in:	RNA biology Vol. 14; no. 8; pp. 978 - 984
Main Authors:	Noto, John J., Schmidt, Casey A., Matera, A. Gregory
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 03.08.2017
Subjects:	Animals Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Archaea Archaea - genetics Archaea - metabolism Back-splicing biogenesis circRNA circular RNA Drosophila melanogaster - genetics Drosophila melanogaster - metabolism ectopic gene expression Exons Genetic Engineering - methods HEK293 Cells HeLa Cells Humans Introns Mice Point of Views RNA - genetics RNA - metabolism RNA aptamers RNA Precursors - genetics RNA Precursors - metabolism RNA Splice Sites RNA Splicing RNA, Transfer - genetics RNA, Transfer - metabolism Spliceosomes - metabolism Spliceosomes - ultrastructure transfer RNA tricRNA tRNA processing RNA aptamers ectopic gene expression Back-splicing circRNA tRNA processing tricRNA
ISSN:	1547-6286, 1555-8584, 1555-8584
Online Access:	Get full text
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