Engineering and expressing circular RNAs via tRNA splicing

Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here,...

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Vydáno v:	RNA biology Ročník 14; číslo 8; s. 978 - 984
Hlavní autoři:	Noto, John J., Schmidt, Casey A., Matera, A. Gregory
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 03.08.2017
Témata:	Animals Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Archaea Archaea - genetics Archaea - metabolism Back-splicing biogenesis circRNA circular RNA Drosophila melanogaster - genetics Drosophila melanogaster - metabolism ectopic gene expression Exons Genetic Engineering - methods HEK293 Cells HeLa Cells Humans Introns Mice Point of Views RNA - genetics RNA - metabolism RNA aptamers RNA Precursors - genetics RNA Precursors - metabolism RNA Splice Sites RNA Splicing RNA, Transfer - genetics RNA, Transfer - metabolism Spliceosomes - metabolism Spliceosomes - ultrastructure transfer RNA tricRNA tRNA processing RNA aptamers ectopic gene expression Back-splicing circRNA tRNA processing tricRNA
ISSN:	1547-6286, 1555-8584, 1555-8584
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Abstract	Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.
AbstractList	Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo. Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.
Author	Schmidt, Casey A. Noto, John J. Matera, A. Gregory
Author_xml	– sequence: 1 givenname: John J. surname: Noto fullname: Noto, John J. organization: Integrative Program for Biological and Genome Sciences, The University of North Carolina at Chapel Hill – sequence: 2 givenname: Casey A. surname: Schmidt fullname: Schmidt, Casey A. organization: Integrative Program for Biological and Genome Sciences, The University of North Carolina at Chapel Hill – sequence: 3 givenname: A. Gregory orcidid: 0000-0002-6406-0630 surname: Matera fullname: Matera, A. Gregory email: matera@unc.edu organization: Department of Genetics, The University of North Carolina at Chapel Hill
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28402213$$D View this record in MEDLINE/PubMed
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Snippet	Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with...
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SubjectTerms	Animals Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Archaea Archaea - genetics Archaea - metabolism Back-splicing biogenesis circRNA circular RNA Drosophila melanogaster - genetics Drosophila melanogaster - metabolism ectopic gene expression Exons Genetic Engineering - methods HEK293 Cells HeLa Cells Humans Introns Mice Point of Views RNA - genetics RNA - metabolism RNA aptamers RNA Precursors - genetics RNA Precursors - metabolism RNA Splice Sites RNA Splicing RNA, Transfer - genetics RNA, Transfer - metabolism Spliceosomes - metabolism Spliceosomes - ultrastructure transfer RNA tricRNA tRNA processing
Title	Engineering and expressing circular RNAs via tRNA splicing
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