Critical role of mammalian target of rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization

Fusion proteins incorporating the Toll-like receptor 5 ligand flagellin are currently undergoing clinical trials as vaccine candidates for many diseases. We studied the mechanisms of immune modulation by a flagellin:allergen fusion protein containing the Toll-like receptor 5 ligand flagellin A from...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 141; no. 5; pp. 1786 - 1798.e11
Main Authors:	Schülke, Stefan, Fiedler, Anna-Helena, Junker, Ann-Christine, Flaczyk, Adam, Wolfheimer, Sonja, Wangorsch, Andrea, Heinz, Anke, Beckert, Hendrik, Nagl, Birgit, Bohle, Barbara, Vieths, Stefan, Toda, Masako, Scheurer, Stephan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.05.2018 Elsevier Limited
Subjects:	Allergens Allergies Antigens Bet v 1 Bet v 1 antigen birch pollen allergy Bone marrow CD4 antigen Cell activation Clinical trials Cytokines Dendritic cells Flagellin Fusion protein IL-10 dendritic cell Immunomodulation Inflammation Influenza Interleukin 10 Kinases Labeling Ligands Listeria monocytogenes Lymphocytes T mammalian target of rapamycin Metabolic rate metabolism Penicillin Pollen Proteins Rapamycin rFlaA Salmonella Toll-like receptors TOR protein Vaccine Vaccines West Nile virus Germany FlaA FACS EGFP MyD88 2-DO mammalian target of rapamycin FITC NADH PI3K PRAS40 mTOR flagellin birch pollen allergy TLR IL-10 dendritic cell Vaccine mDC alum fusion protein APC B/A PE metabolism OVA Bet v 1 rFlaA DC
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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