Integrating the predictiveness of a marker with its performance as a classifier

There are two popular statistical approaches to biomarker evaluation. One models the risk of disease (or disease outcome) with, for example, logistic regression. A marker is considered useful if it has a strong effect on risk. The second evaluates classification performance by use of measures such a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of epidemiology Jg. 167; H. 3; S. 362
Hauptverfasser: Pepe, Margaret S, Feng, Ziding, Huang, Ying, Longton, Gary, Prentice, Ross, Thompson, Ian M, Zheng, Yingye
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.02.2008
Schlagworte:
Biomarkers - analysis
Epidemiologic Methods
Humans
Logistic Models
Male
Models, Theoretical
Predictive Value of Tests
Prostate-Specific Antigen - blood
Risk
Risk Assessment - methods
ROC Curve
Sensitivity and Specificity
ISSN:1476-6256, 1476-6256
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:There are two popular statistical approaches to biomarker evaluation. One models the risk of disease (or disease outcome) with, for example, logistic regression. A marker is considered useful if it has a strong effect on risk. The second evaluates classification performance by use of measures such as sensitivity, specificity, predictive values, and receiver operating characteristic curves. There is controversy about which approach is more appropriate. Moreover, the two approaches can give contradictory results on the same data. The authors present a new graphic, the predictiveness curve, which complements the risk modeling approach. It assesses the usefulness of a risk model when applied to the population. Although the predictiveness curve relates to classification performance measures, it also displays essential information about risk that is not displayed by the receiver operating characteristic curve. The authors propose that the predictiveness and classification performance of a marker, displayed together in an integrated plot, provide a comprehensive and cohesive assessment of a risk marker or model. The methods are demonstrated with data on prostate-specific antigen and risk factors from the Prostate Cancer Prevention Trial, 1993-2003.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1476-6256
1476-6256
DOI:10.1093/aje/kwm305