A prospective case-control study on the association of Rhinovirus nasopharyngeal viral load and viremia in South African children hospitalized with severe pneumonia

•Rhinovirus role during severe childhood respiratory disease remains unknown.•Rhinovirus prevalence was similar between children with pneumonia and controls.•Rhinovirus-viremia was 4-fold more prevalent amongst cases than controls.•Viremia could be helpful in attributing causality to rhinovirus duri...

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Veröffentlicht in:Journal of clinical virology Jg. 125; S. 104288
Hauptverfasser: Baillie, Vicky L., Moore, David P., Mathunjwa, Azwifarwi, Morailane, Palesa, Simões, Eric A.F., Madhi, Shabir A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.04.2020
The Authors. Published by Elsevier B.V
Schlagworte:
Children
Molecular epidemiology
Pneumonia
Rhinovirus
Viral load
Viremia
Molecular epidemiology
Pneumonia
Children
Viremia
Viral load
Rhinovirus
ISSN:1386-6532, 1873-5967, 1873-5967
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Zusammenfassung:•Rhinovirus role during severe childhood respiratory disease remains unknown.•Rhinovirus prevalence was similar between children with pneumonia and controls.•Rhinovirus-viremia was 4-fold more prevalent amongst cases than controls.•Viremia could be helpful in attributing causality to rhinovirus during pneumonia episodes. Rhinovirus (RV) role in pathogenesis of severe childhood disease remains controversial. We aimed to explore the association between RV molecular subtyping, nasopharyngeal viral loads and viremia with childhood pneumonia. Nasopharyngeal and blood samples from cases and controls were tested for RV and the 5′ non-coding region sequenced. The cases compared to controls had a similar prevalence of RV detection in the nasopharynx (23 % vs. 22 %, P = 0.66), similar RV species distribution (A, B, C = 44 %, 8%, 44 % vs. 48 %, 7%, 38 %; respectively; P = 0.66) and similar viral load (4.0 and 3.7 log10 copies/mL, P = 0.062). However, RV-viremia was 4.01-fold (aOR 95 % CI: 1.26–12.78) more prevalent among cases (7%) than controls (2%), P = 0.019. Furthermore, among cases and controls RV-C was more commonly associated with viremia (14 % and 4%, P = 0.023), than RV-A (2% and 1%; P = 0.529). Thus RV-viremia could be used as a measure for attributing causality to RV in children hospitalized for pneumonia.
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Co-Senior authors.
ISSN:1386-6532
1873-5967
1873-5967
DOI:10.1016/j.jcv.2020.104288