Gut-derived endotoxin stimulates factor VIII secretion from endothelial cells. Implications for hypercoagulability in cirrhosis

[Display omitted] •Cirrhosis is associated with thrombosis in portal and systemic circulation.•Cirrhosis display a concomitant increase of factor VIII and LPS from E. Coli.•LPS contributes to release factor VIII from endothelial cells. Patients with cirrhosis display enhanced blood levels of factor...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 67; no. 5; pp. 950 - 956
Main Authors:	Carnevale, Roberto, Raparelli, Valeria, Nocella, Cristina, Bartimoccia, Simona, Novo, Marta, Severino, Anna, De Falco, Elena, Cammisotto, Vittoria, Pasquale, Chiara, Crescioli, Clara, Scavalli, Antonio Sili, Riggio, Oliviero, Basili, Stefania, Violi, Francesco
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2017 Elsevier Science Ltd
Subjects:	Blood clots Blood levels Blood tests Cellular biology Cirrhosis Clotting Coagulation factors Cross-Sectional Studies Deoxyribonucleic acid DNA DNA, Bacterial - analysis Endothelial cells Endothelium Endotoxin Endotoxins - metabolism Escherichia coli Escherichia coli - genetics Factor VIII Factor VIII - analysis Factor VIII - secretion Female Gastrointestinal Microbiome - physiology Human Umbilical Vein Endothelial Cells - metabolism Humans Hypercoagulability Intestinal microflora Italy Lipopolysaccharides Lipopolysaccharides - analysis Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - complications LPS Male Microbiota Middle Aged Patients Secretion Serum levels Thrombophilia - diagnosis Thrombophilia - etiology Thrombophilia - metabolism Thrombosis TLR4 protein Toll-like receptors Umbilical vein Von Willebrand factor von Willebrand Factor - analysis von Willebrand Factor - secretion Weibel-Palade Bodies - metabolism Hypercoagulability Cirrhosis Endotoxin von Willebrand factor LPS Factor VIII
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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