Liver fibrosis in patients with metabolic associated fatty liver disease is a risk factor for adverse outcomes in COVID-19

Metabolic diseases are risk factors for severe Coronavirus disease (COVID-19), which have a close relationship with metabolic dysfunction-associated fatty liver disease (MAFLD). To evaluate the presence of MAFLD and fibrosis in patients with COVID-19 and its association with prognosis. Retrospective...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Digestive and liver disease Jg. 53; H. 5; S. 525 - 533
Hauptverfasser: Campos-Murguía, Alejandro, Román-Calleja, Berenice Monserrat, Toledo-Coronado, Israel Vicente, González-Regueiro, José Alberto, Solís-Ortega, Alberto Adrián, Kúsulas-Delint, Deyanira, Cruz-Contreras, Mariana, Cruz-Yedra, Nabila, Cubero, Francisco Javier, Nevzorova, Yulia Alexandrowna, Martínez-Cabrera, Carlos Fernando, Moreno-Guillén, Paulina, Lozano-Cruz, Oscar Arturo, Chapa-Ibargüengoitia, Mónica, Gulías-Herrero, Alfonso, Aguilar-Salinas, Carlos Alberto, Ruiz-Margáin, Astrid, Macías-Rodríguez, Ricardo Ulises
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 01.05.2021
Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd
Schlagworte:
Aspartate Aminotransferases - blood
Biomarkers - blood
Blood Platelets - pathology
computed tomography
COVID-19 - blood
COVID-19 - complications
COVID-19 - mortality
COVID-19 - therapy
Fatty Liver - diagnosis
Fatty Liver - epidemiology
Fatty Liver - metabolism
Female
Humans
Liver - diagnostic imaging
Liver - metabolism
Liver - pathology
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Liver Cirrhosis - metabolism
Liver Function Tests - methods
liver steatosis
Liver, Pancreas and Biliary Tract
Male
Mexico - epidemiology
Middle Aged
Prognosis
Research Design
Respiration, Artificial - statistics & numerical data
Retrospective Studies
Risk Factors
SARS-CoV-2
Severity of Illness Index
Tomography, X-Ray Computed - methods
Mexico
computed tomography
liver steatosis
SARS-CoV-2
prognosis
ISSN:1590-8658, 1878-3562, 1878-3562
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Metabolic diseases are risk factors for severe Coronavirus disease (COVID-19), which have a close relationship with metabolic dysfunction-associated fatty liver disease (MAFLD). To evaluate the presence of MAFLD and fibrosis in patients with COVID-19 and its association with prognosis. Retrospective cohort study. In hospitalized patients with COVID-19, the presence of liver steatosis was determined by computed tomography scan (CT). Liver fibrosis was assessed using the NAFLD fibrosis score (NFS score), and when altered, the AST to platelet ratio index (APRI) score. Mann-Whitney U, Student´s t-test, logistic regression analysis, Kaplan-Meier curves and Cox regression analysis were used. 432 patients were analyzed, finding steatosis in 40.6%. No differences in pulmonary involvement on CT scan, treatment, or number of days between the onset of symptoms and hospital admission were found between patients with and without MAFLD. The presence of liver fibrosis was associated with higher severity scores, higher levels of inflammatory markers, requirement of mechanical ventilation, incidence of acute kidney injury (AKI), and higher mortality than patients without fibrosis. The presence of fibrosis rather than the presence of MAFLD is associated with increased risk for mechanical ventilation, development of AKI, and higher mortality in COVID-19 patients.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1590-8658
1878-3562
1878-3562
DOI:10.1016/j.dld.2021.01.019