Cell pathology in bipolar disorder
Objectives: The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD. Methods: Reports of alterations in n...
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| Published in: | Bipolar disorders Vol. 4; no. 2; pp. 105 - 116 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford UK
Munksgaard International Publishers
01.04.2002
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| Subjects: | |
| ISSN: | 1398-5647, 1399-5618 |
| Online Access: | Get full text |
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| Abstract | Objectives:
The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD.
Methods:
Reports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, s of recent symposia are also discussed.
Results and Conclusions:
In BPD, significant reductions in the volume of several brain regions, as well as region‐ and layer‐specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD. |
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| AbstractList | The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD.OBJECTIVESThe objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD.Reports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, abstracts of recent symposia are also discussed.METHODSReports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, abstracts of recent symposia are also discussed.In BPD. significant reductions in the volume of several brain regions, as well as region- and layer-specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD.RESULTS AND CONCLUSIONSIn BPD. significant reductions in the volume of several brain regions, as well as region- and layer-specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD. Objectives: The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD. Methods: Reports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, abstracts of recent symposia are also discussed. Results and Conclusions: In BPD, significant reductions in the volume of several brain regions, as well as region‐ and layer‐specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD. Objectives: The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD. Methods: Reports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, abstracts of recent symposia are also discussed. Results and Conclusions: In BPD, significant reductions in the volume of several brain regions, as well as region- and layer-specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD. The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD. Reports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, abstracts of recent symposia are also discussed. In BPD. significant reductions in the volume of several brain regions, as well as region- and layer-specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD. Objectives: The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) to demonstrate that impairments of cell morphology and resilience may underlie the neurobiology of BPD. Methods: Reports of alterations in number, density and size of neurons and glial cells in BPD are reviewed. Owing to the low number of postmortem studies on cellular pathology in BPD, s of recent symposia are also discussed. Results and Conclusions: In BPD, significant reductions in the volume of several brain regions, as well as region‐ and layer‐specific reductions in the number, density and/or size of neurons and glial cells have been demonstrated. Moreover, the results of recent clinical and preclinical studies investigating the molecular and cellular targets of mood stabilizing and antidepressant medications provide intriguing possibilities that impairments in neuroplasticity and cellular resilience may underlie the neurobiology of BPD. Future studies will likely examine the role of both genetic and environmental factors in the pathogenesis and cellular changes in BPD. |
| Author | Rajkowska, Grazyna |
| Author_xml | – sequence: 1 givenname: Grazyna surname: Rajkowska fullname: Rajkowska, Grazyna organization: Laboratory of Quantitative Neuroanatomy, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12071508$$D View this record in MEDLINE/PubMed |
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| PublicationPlace | Oxford UK |
| PublicationPlace_xml | – name: Oxford UK – name: Denmark |
| PublicationTitle | Bipolar disorders |
| PublicationTitleAlternate | Bipolar Disord |
| PublicationYear | 2002 |
| Publisher | Munksgaard International Publishers |
| Publisher_xml | – name: Munksgaard International Publishers |
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Chen G, Zeng 2001; 50 1990; 10 1991; 114 2000; 47 2000; 48 2000; 5 1997; 41 1997; 154 1995; 34 1995; 33 2000; 41 1997; 277 1999; 46 1999; 45 2001; 49 1999; 40 1989; 46 1998; 43 1994; 60 1992; 93 1998; 44 1998; 395 1985; 69 1995; 61 1982; 28 1991; 48 1990; 47 1997; 54 2000; 126 1995; 25 1993; 33 1994; 263 1997; 386 1982; 4 1996; 371 2000; 61 1999; 54 1994; 35 1999; 10 1998; 95 2001; 58 1992; 2 1998; 55 2001; 98 1995; 52 1991; 3 1989; 1 1991; 133 1985; 5 1997; 22 2000; 26 1986; 10 1995; 15 1994; 151 1999; 4 2000; 275 1999; 145 1999; 60 1999; 821 1996; 169 1996; 16 1995; 152 1993; 187 1995; 6 1996; 53 1993; 14 1992; 70 1994; 368 1990; 27 1999; 39 1995; 46 1993; 54 1999; 36 2000; 75 1999; 274 1996; 153 1999; 73 1999; 156 1999; 354 1999; 72 1998; 149 1999; 877 1996; 279 1998; 78 1998; 9 1990; 5 1994; 6 George MS (e_1_2_8_22_2) 1993; 54 e_1_2_8_49_2 e_1_2_8_45_2 e_1_2_8_26_2 e_1_2_8_68_2 e_1_2_8_9_2 Pandey GN (e_1_2_8_70_2) 1999; 156 Orlovskaya DD (e_1_2_8_41_2) 1999; 36 e_1_2_8_5_2 Bowley MP (e_1_2_8_36_2) 2000; 26 e_1_2_8_87_2 e_1_2_8_64_2 e_1_2_8_83_2 e_1_2_8_60_2 e_1_2_8_38_2 e_1_2_8_19_2 e_1_2_8_109_2 e_1_2_8_34_2 e_1_2_8_15_2 e_1_2_8_57_2 e_1_2_8_91_2 e_1_2_8_95_2 Shimizu M (e_1_2_8_51_2) 1996; 279 e_1_2_8_99_2 e_1_2_8_30_2 e_1_2_8_76_2 e_1_2_8_105_2 e_1_2_8_11_2 e_1_2_8_53_2 e_1_2_8_72_2 e_1_2_8_101_2 e_1_2_8_25_2 e_1_2_8_48_2 e_1_2_8_67_2 Manji HK (e_1_2_8_89_2) 2000; 61 e_1_2_8_2_2 e_1_2_8_6_2 e_1_2_8_21_2 e_1_2_8_44_2 e_1_2_8_63_2 e_1_2_8_86_2 e_1_2_8_40_2 e_1_2_8_18_2 e_1_2_8_14_2 e_1_2_8_37_2 e_1_2_8_56_2 e_1_2_8_79_2 e_1_2_8_90_2 e_1_2_8_94_2 e_1_2_8_98_2 e_1_2_8_10_2 e_1_2_8_33_2 e_1_2_8_52_2 e_1_2_8_75_2 e_1_2_8_106_2 e_1_2_8_71_2 e_1_2_8_102_2 e_1_2_8_28_2 e_1_2_8_24_2 e_1_2_8_47_2 e_1_2_8_3_2 e_1_2_8_7_2 e_1_2_8_20_2 e_1_2_8_66_2 e_1_2_8_43_2 e_1_2_8_85_2 e_1_2_8_62_2 e_1_2_8_81_2 Blumberg HP (e_1_2_8_4_2) 1999; 156 e_1_2_8_17_2 e_1_2_8_13_2 e_1_2_8_59_2 e_1_2_8_78_2 e_1_2_8_97_2 e_1_2_8_55_2 Bertolino A (e_1_2_8_29_2) 1999; 45 e_1_2_8_32_2 e_1_2_8_74_2 e_1_2_8_107_2 e_1_2_8_93_2 e_1_2_8_103_2 e_1_2_8_27_2 e_1_2_8_23_2 e_1_2_8_46_2 e_1_2_8_69_2 e_1_2_8_80_2 Manji HK (e_1_2_8_82_2) 1999; 60 e_1_2_8_8_2 e_1_2_8_42_2 e_1_2_8_65_2 e_1_2_8_88_2 e_1_2_8_61_2 e_1_2_8_84_2 e_1_2_8_16_2 e_1_2_8_39_2 e_1_2_8_12_2 e_1_2_8_35_2 e_1_2_8_58_2 e_1_2_8_108_2 e_1_2_8_96_2 e_1_2_8_31_2 e_1_2_8_54_2 e_1_2_8_77_2 e_1_2_8_104_2 e_1_2_8_50_2 e_1_2_8_73_2 e_1_2_8_100_2 e_1_2_8_92_2 15005758 - Bipolar Disord. 2004 Apr;6(2):168-9 |
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| SubjectTerms | Bipolar Disorder - pathology Brain - pathology Cell Count frontal cortex glia Humans mood disorders Nerve Degeneration - pathology Neuroglia - pathology neuropathology postmortem |
| Title | Cell pathology in bipolar disorder |
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