Predictable increase in female reproductive window: A simple model connecting age of reproduction, menopause, and longevity

With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to...

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Vydané v:BioEssays Ročník 43; číslo 5; s. e2000233 - n/a
Hlavní autori: Innan, Hideki, Vaiman, Daniel, Veitia, Reiner A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley 01.05.2021
Wiley Subscription Services, Inc
Predmet:
age at menopause
Alleles
DNA recombination
DNA repair
Epigenetics
Female
female fertility
female infertility
female subfertility
Females
Fertility
Genetic diversity
Genetic variance
Humans
Infertility
Life span
lifestyle
Longevity
Menopause
Model testing
Reproduction
female subfertility
DNA recombination
female infertility
DNA repair
age at menopause
ISSN:0265-9247, 1521-1878, 1521-1878
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Abstract With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle. Pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. As women marry later than in previous centuries, we speculate that a logical consequence would be the later occurrence of menopause and the extension of their reproductive window.
AbstractList With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle. Pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. As women marry later than in previous centuries, we speculate that a logical consequence would be the later occurrence of menopause and the extension of their reproductive window.
With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle.
With the ever-increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter-selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle.With the ever-increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter-selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle.
Author Hideki Innan
Daniel Vaiman
Reiner A. Veitia
Author_xml – sequence: 1
  givenname: Hideki
  surname: Innan
  fullname: Innan, Hideki
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  givenname: Daniel
  surname: Vaiman
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  givenname: Reiner A.
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  surname: Veitia
  fullname: Veitia, Reiner A.
  email: reiner.veitia@ijm.fr
  organization: Université Paris‐Saclay
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Keywords female subfertility
DNA recombination
female infertility
DNA repair
age at menopause
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Snippet With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic...
With the ever-increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic...
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StartPage e2000233
SubjectTerms age at menopause
Alleles
DNA recombination
DNA repair
Epigenetics
Female
female fertility
female infertility
female subfertility
Females
Fertility
Genetic diversity
Genetic variance
Humans
Infertility
Life span
lifestyle
Longevity
Menopause
Model testing
Reproduction
Title Predictable increase in female reproductive window: A simple model connecting age of reproduction, menopause, and longevity
URI https://cir.nii.ac.jp/crid/1872272492456001152
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbies.202000233
https://www.ncbi.nlm.nih.gov/pubmed/33569823
https://www.proquest.com/docview/2514351167
https://www.proquest.com/docview/2488569534
https://www.proquest.com/docview/2551943984
Volume 43
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