Preexisting High Expression of Matrix Metalloproteinase-2 in Tunica Media of Saphenous Vein Conduits Is Associated with Unfavorable Long-Term Outcomes after Coronary Artery Bypass Grafting

Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV...

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Vydané v:	BioMed research international Ročník 2013; číslo 2013; s. 1 - 9
Hlavní autori:	Nowicki, Michał, Zabel, Maciej, Ostalska-Nowicka, Danuta, Misterski, Marcin, Malinska, Agnieszka, Perek, Bartlomiej, Perek, Anna
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cairo, Egypt Hindawi Publishing Corporation 01.01.2013 John Wiley & Sons, Inc
Predmet:	Adult Aged Aged, 80 and over Aging Atherosclerosis Cardiovascular disease Colleges & universities Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary vessels Diabetes Female Gene Expression Regulation Heart attacks Heart surgery Humans Hypertension Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - metabolism Medical imaging Middle Aged Multivariate analysis Myocytes, Smooth Muscle - metabolism Saphenous Vein - metabolism Saphenous Vein - pathology Smoking Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-3 - biosynthesis Treatment Outcome Tunica Media - metabolism Tunica Media - pathology
ISSN:	2314-6133, 2314-6141, 2314-6141
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Abstract	Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Methods. Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n=47) or without it (SVGD (−); n=153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. Results. In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (−) patients. In majority of the SV segments obtained from the SVGD (−) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. Conclusion. The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes.
AbstractList	Introduction . Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Methods . Two hundred consecutive patients with a mean age of 63.1 plus or minus 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n=47) or without it (SVGD (-); n=153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. Results . In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (-) patients. In majority of the SV segments obtained from the SVGD (-) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. Conclusion . The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes. Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts.INTRODUCTIONMigration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts.Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n = 47) or without it (SVGD (-); n = 153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed.METHODSTwo hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n = 47) or without it (SVGD (-); n = 153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed.In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (-) patients. In majority of the SV segments obtained from the SVGD (-) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects.RESULTSIn the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (-) patients. In majority of the SV segments obtained from the SVGD (-) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects.The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes.CONCLUSIONThe strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes. Introduction. Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Methods. Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n=47 ) or without it (SVGD (-); n=153 ). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. Results. In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (-) patients. In majority of the SV segments obtained from the SVGD (-) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. Conclusion. The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes. Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Methods. Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n=47) or without it (SVGD (−); n=153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. Results. In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (−) patients. In majority of the SV segments obtained from the SVGD (−) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. Conclusion. The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes. Introduction. Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Methods. Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n=47) or without it (SVGD (−); n=153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. Results. In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (−) patients. In majority of the SV segments obtained from the SVGD (−) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. Conclusion. The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes. Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n = 47) or without it (SVGD (-); n = 153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (-) patients. In majority of the SV segments obtained from the SVGD (-) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes.
Author	Misterski, Marcin Nowicki, Michał Perek, Anna Malinska, Agnieszka Perek, Bartlomiej Ostalska-Nowicka, Danuta Zabel, Maciej
AuthorAffiliation	2 Histology and Embryology, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland 4 Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland 1 Departments of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland 3 Pediatric Cardiology and Nephrology, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland
AuthorAffiliation_xml	– name: 1 Departments of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland – name: 3 Pediatric Cardiology and Nephrology, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland – name: 4 Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland – name: 2 Histology and Embryology, Poznan University of Medical Sciences, ul. Dluga 1/2, 61-848 Poznan, Poland
Author_xml	– sequence: 1 fullname: Nowicki, Michał – sequence: 2 fullname: Zabel, Maciej – sequence: 3 fullname: Ostalska-Nowicka, Danuta – sequence: 4 fullname: Misterski, Marcin – sequence: 5 fullname: Malinska, Agnieszka – sequence: 6 fullname: Perek, Bartlomiej – sequence: 7 fullname: Perek, Anna
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24151618$$D View this record in MEDLINE/PubMed
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Copyright	Copyright © 2013 Bartlomiej Perek et al. Copyright © 2013 Bartlomiej Perek et al. Bartlomiej Perek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 Bartlomiej Perek et al. 2013
Copyright_xml	– notice: Copyright © 2013 Bartlomiej Perek et al. – notice: Copyright © 2013 Bartlomiej Perek et al. Bartlomiej Perek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. – notice: Copyright © 2013 Bartlomiej Perek et al. 2013
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Snippet	Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The... Introduction. Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix... Introduction . Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix...
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SubjectTerms	Adult Aged Aged, 80 and over Aging Atherosclerosis Cardiovascular disease Colleges & universities Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary vessels Diabetes Female Gene Expression Regulation Heart attacks Heart surgery Humans Hypertension Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - metabolism Medical imaging Middle Aged Multivariate analysis Myocytes, Smooth Muscle - metabolism Saphenous Vein - metabolism Saphenous Vein - pathology Smoking Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-3 - biosynthesis Treatment Outcome Tunica Media - metabolism Tunica Media - pathology
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Title	Preexisting High Expression of Matrix Metalloproteinase-2 in Tunica Media of Saphenous Vein Conduits Is Associated with Unfavorable Long-Term Outcomes after Coronary Artery Bypass Grafting
URI	https://search.emarefa.net/detail/BIM-1004980 https://dx.doi.org/10.1155/2013/730721 https://www.ncbi.nlm.nih.gov/pubmed/24151618 https://www.proquest.com/docview/1441567767 https://www.proquest.com/docview/1443374243 https://www.proquest.com/docview/1444859443 https://pubmed.ncbi.nlm.nih.gov/PMC3787554
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