Preexisting High Expression of Matrix Metalloproteinase-2 in Tunica Media of Saphenous Vein Conduits Is Associated with Unfavorable Long-Term Outcomes after Coronary Artery Bypass Grafting

Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV...

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Published in:BioMed research international Vol. 2013; no. 2013; pp. 1 - 9
Main Authors: Nowicki, Michał, Zabel, Maciej, Ostalska-Nowicka, Danuta, Misterski, Marcin, Malinska, Agnieszka, Perek, Bartlomiej, Perek, Anna
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2013
John Wiley & Sons, Inc
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Atherosclerosis
Cardiovascular disease
Colleges & universities
Coronary Artery Bypass - adverse effects
Coronary Artery Bypass - methods
Coronary vessels
Diabetes
Female
Gene Expression Regulation
Heart attacks
Heart surgery
Humans
Hypertension
Male
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 2 - metabolism
Medical imaging
Middle Aged
Multivariate analysis
Myocytes, Smooth Muscle - metabolism
Saphenous Vein - metabolism
Saphenous Vein - pathology
Smoking
Tissue Inhibitor of Metalloproteinase-2 - biosynthesis
Tissue Inhibitor of Metalloproteinase-3 - biosynthesis
Treatment Outcome
Tunica Media - metabolism
Tunica Media - pathology
ISSN:2314-6133, 2314-6141, 2314-6141
Online Access:Get full text
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Summary:Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV segments and late failure of the SV grafts. Methods. Two hundred consecutive patients with a mean age of 63.1 ± 8.9 years who underwent primary isolated venous CABG were examined. Patients were retrospectively split into two subgroups, with the SV graft disease (SVGD (+); n=47) or without it (SVGD (−); n=153). In the SV segments, immunohistochemical analysis of the expression of the MMP-2, TIMP-2, and -3 was performed. Results. In the SVGD (+) patients, tissue expression of MMP-2 was stronger, whereas that of both TIMPs was weaker than in the SVGD (−) patients. In majority of the SV segments obtained from the SVGD (−) individuals, a balance in MMP and TIMP expressions was found, whereas an upregulation of MMP-2 expression was usually noted in the SVGD (+) subjects. Conclusion. The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable CABG outcomes.
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Academic Editor: Rei Shibata
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2013/730721