Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

In chronic kidney disease (CKD), uremic solutes accumulate in blood and tissues. These compounds probably contribute to the marked increase in cardiovascular risk during the progression of CKD. The uremic solutes indoxyl sulfate and indole-3-acetic acid (IAA) are particularly deleterious for endothe...

Full description

Saved in:

Bibliographic Details
Published in:	Kidney international Vol. 84; no. 4; pp. 733 - 744
Main Authors:	Gondouin, Bertrand, Cerini, Claire, Dou, Laetitia, Sallée, Marion, Duval-Sabatier, Ariane, Pletinck, Anneleen, Calaf, Raymond, Lacroix, Romaric, Jourde-Chiche, Noémie, Poitevin, Stéphane, Arnaud, Laurent, Vanholder, Raymond, Brunet, Philippe, Dignat-George, Françoise, Burtey, Stéphane
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2013 Elsevier Limited Nature Publishing Group
Subjects:	Adult Aged Aged, 80 and over aryl hydrocarbon receptor Benzoquinones - pharmacology Cardiology and cardiovascular system Case-Control Studies Cells, Cultured Dioxins - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Human health and pathology Humans In Vitro Techniques Indican - metabolism Indican - pharmacology Indoleacetic Acids - metabolism Indoleacetic Acids - pharmacology Lactams, Macrocyclic - pharmacology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Life Sciences Male Middle Aged Polymerase Chain Reaction Receptors, Aryl Hydrocarbon - antagonists & inhibitors Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism Renal Insufficiency, Chronic - metabolism RNA, Small Interfering - pharmacology Signal Transduction - drug effects Signal Transduction - physiology Thromboplastin - metabolism Tissue Array Analysis tissue factor Umbilical Veins - cytology Umbilical Veins - drug effects Umbilical Veins - metabolism Up-Regulation - drug effects Up-Regulation - physiology uremic solutes Urology and Nephrology tissue factor uremic solutes aryl hydrocarbon receptor
ISSN:	0085-2538, 1523-1755, 1523-1755
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!