Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data
Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepin...
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| Published in: | The Science of the total environment Vol. 442; pp. 380 - 388 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Kidlington
Elsevier B.V
01.01.2013
Elsevier |
| Subjects: | |
| ISSN: | 0048-9697, 1879-1026, 1879-1026 |
| Online Access: | Get full text |
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| Abstract | Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepine, predicted emissions were compared to wastewater concentrations, removal in sewage treatment plants and recovery in regional surface water. The study shows that local consumption data can be very useful to select pharmaceuticals for monitoring and to predict wastewater concentrations. Measured influent concentrations were on average 78% with a range of 31–138% of predicted influent concentrations. Metformin is the pharmaceutical with the highest concentration in wastewater (64–98μg/L) but it is removed with >98% in sewage treatment plants (STP). Guanylurea, a biodegradation product of metformin, was detected in STP effluents and surface waters at concentrations of 39–56μg/L and 1.8–3.9μg/L, respectively. The STP removal of the different pharmaceuticals varied strongly. For carbamazepine, hydrochlorothiazide and sotalol a significant better removal was found at higher temperatures and longer hydraulic retention times while for metoprolol significantly better removal was only observed at higher temperatures. Predicting environmental concentrations from regional consumption data might be an alternative to monitoring of pharmaceuticals in wastewater and surface waters.
► Regional sales relevant for monitoring and emission prediction of pharmaceuticals ► Metformin concentrations are 80μg/L and 1μg/L in wastewater and effluent respectively. ► 82% of metformin in wastewater recovered as guanylurea in effluent. ► Significant better removal at higher temperatures for 4 of 9 pharmaceuticals ► Significant better removal at higher HRTs for 3 of 9 pharmaceuticals |
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| AbstractList | Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepine, predicted emissions were compared to wastewater concentrations, removal in sewage treatment plants and recovery in regional surface water. The study shows that local consumption data can be very useful to select pharmaceuticals for monitoring and to predict wastewater concentrations. Measured influent concentrations were on average 78% with a range of 31-138% of predicted influent concentrations. Metformin is the pharmaceutical with the highest concentration in wastewater (64-98 μg/L) but it is removed with >98% in sewage treatment plants (STP). Guanylurea, a biodegradation product of metformin, was detected in STP effluents and surface waters at concentrations of 39-56 μg/L and 1.8-3.9 μg/L, respectively. The STP removal of the different pharmaceuticals varied strongly. For carbamazepine, hydrochlorothiazide and sotalol a significant better removal was found at higher temperatures and longer hydraulic retention times while for metoprolol significantly better removal was only observed at higher temperatures. Predicting environmental concentrations from regional consumption data might be an alternative to monitoring of pharmaceuticals in wastewater and surface waters.Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepine, predicted emissions were compared to wastewater concentrations, removal in sewage treatment plants and recovery in regional surface water. The study shows that local consumption data can be very useful to select pharmaceuticals for monitoring and to predict wastewater concentrations. Measured influent concentrations were on average 78% with a range of 31-138% of predicted influent concentrations. Metformin is the pharmaceutical with the highest concentration in wastewater (64-98 μg/L) but it is removed with >98% in sewage treatment plants (STP). Guanylurea, a biodegradation product of metformin, was detected in STP effluents and surface waters at concentrations of 39-56 μg/L and 1.8-3.9 μg/L, respectively. The STP removal of the different pharmaceuticals varied strongly. For carbamazepine, hydrochlorothiazide and sotalol a significant better removal was found at higher temperatures and longer hydraulic retention times while for metoprolol significantly better removal was only observed at higher temperatures. Predicting environmental concentrations from regional consumption data might be an alternative to monitoring of pharmaceuticals in wastewater and surface waters. Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepine, predicted emissions were compared to wastewater concentrations, removal in sewage treatment plants and recovery in regional surface water. The study shows that local consumption data can be very useful to select pharmaceuticals for monitoring and to predict wastewater concentrations. Measured influent concentrations were on average 78% with a range of 31–138% of predicted influent concentrations. Metformin is the pharmaceutical with the highest concentration in wastewater (64–98μg/L) but it is removed with >98% in sewage treatment plants (STP). Guanylurea, a biodegradation product of metformin, was detected in STP effluents and surface waters at concentrations of 39–56μg/L and 1.8–3.9μg/L, respectively. The STP removal of the different pharmaceuticals varied strongly. For carbamazepine, hydrochlorothiazide and sotalol a significant better removal was found at higher temperatures and longer hydraulic retention times while for metoprolol significantly better removal was only observed at higher temperatures. Predicting environmental concentrations from regional consumption data might be an alternative to monitoring of pharmaceuticals in wastewater and surface waters. Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepine, predicted emissions were compared to wastewater concentrations, removal in sewage treatment plants and recovery in regional surface water. The study shows that local consumption data can be very useful to select pharmaceuticals for monitoring and to predict wastewater concentrations. Measured influent concentrations were on average 78% with a range of 31-138% of predicted influent concentrations. Metformin is the pharmaceutical with the highest concentration in wastewater (64-98 μg/L) but it is removed with >98% in sewage treatment plants (STP). Guanylurea, a biodegradation product of metformin, was detected in STP effluents and surface waters at concentrations of 39-56 μg/L and 1.8-3.9 μg/L, respectively. The STP removal of the different pharmaceuticals varied strongly. For carbamazepine, hydrochlorothiazide and sotalol a significant better removal was found at higher temperatures and longer hydraulic retention times while for metoprolol significantly better removal was only observed at higher temperatures. Predicting environmental concentrations from regional consumption data might be an alternative to monitoring of pharmaceuticals in wastewater and surface waters. Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high consumption pharmaceuticals: metformin, metoprolol, sotalol, losartan, valsartan, irbesartan, hydrochlorothiazide, diclofenac and carbamazepine, predicted emissions were compared to wastewater concentrations, removal in sewage treatment plants and recovery in regional surface water. The study shows that local consumption data can be very useful to select pharmaceuticals for monitoring and to predict wastewater concentrations. Measured influent concentrations were on average 78% with a range of 31–138% of predicted influent concentrations. Metformin is the pharmaceutical with the highest concentration in wastewater (64–98μg/L) but it is removed with >98% in sewage treatment plants (STP). Guanylurea, a biodegradation product of metformin, was detected in STP effluents and surface waters at concentrations of 39–56μg/L and 1.8–3.9μg/L, respectively. The STP removal of the different pharmaceuticals varied strongly. For carbamazepine, hydrochlorothiazide and sotalol a significant better removal was found at higher temperatures and longer hydraulic retention times while for metoprolol significantly better removal was only observed at higher temperatures. Predicting environmental concentrations from regional consumption data might be an alternative to monitoring of pharmaceuticals in wastewater and surface waters. ► Regional sales relevant for monitoring and emission prediction of pharmaceuticals ► Metformin concentrations are 80μg/L and 1μg/L in wastewater and effluent respectively. ► 82% of metformin in wastewater recovered as guanylurea in effluent. ► Significant better removal at higher temperatures for 4 of 9 pharmaceuticals ► Significant better removal at higher HRTs for 3 of 9 pharmaceuticals |
| Author | Oosterhuis, Mathijs ter Laak, Thomas L. Sacher, Frank |
| Author_xml | – sequence: 1 givenname: Mathijs surname: Oosterhuis fullname: Oosterhuis, Mathijs email: m.oosterhuis@wrd.nl organization: Water Board Regge en Dinkel P.O. Box 5006, 7600 GA, Almelo, The Netherlands – sequence: 2 givenname: Frank surname: Sacher fullname: Sacher, Frank organization: DVGW-Technologiezentrum Wasser, Karlsruher Straße 84, 76139 Karlsruhe, Germany – sequence: 3 givenname: Thomas L. surname: ter Laak fullname: ter Laak, Thomas L. organization: KWR Watercycle Research Institute, P.O. Box 1072, 3430 BB, Nieuwegein, The Netherlands |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26902100$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/23183121$$D View this record in MEDLINE/PubMed |
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| Copyright | 2012 2014 INIST-CNRS Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved. |
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| Keywords | Guanylurea Regional surface water Metformin Consumption based monitoring Wastewater Pharmaceuticals Drug Urine Biological fluid Elimination Prediction Waste water Hypoglycemic agent Sales Surface water Water quality Emerging pollutant Water pollution Daily dose Monitoring |
| Language | English |
| License | CC BY 4.0 Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved. |
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Results from a pilot study of pharmaceutical removal in Henriksdal WWTP, Sweden publication-title: Water Sci Technol doi: 10.2166/wst.2010.029 – volume: 10 start-page: 664 year: 2008 ident: 10.1016/j.scitotenv.2012.10.046_bb0150 article-title: Pharmaceutical residues in the river Rhine—results of a one-decade monitoring programme publication-title: J Environ Monit doi: 10.1039/b800701b – start-page: 23 year: 2011 ident: 10.1016/j.scitotenv.2012.10.046_bb0205 – volume: 41 start-page: 4471 year: 2007 ident: 10.1016/j.scitotenv.2012.10.046_bb0085 article-title: Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes publication-title: Environ Sci Technol doi: 10.1021/es0627693 – volume: 44 start-page: 605 year: 2010 ident: 10.1016/j.scitotenv.2012.10.046_bb0110 article-title: Determining the fraction of pharmaceuticals residues in wastewater originating from a hospital publication-title: Water Res doi: 10.1016/j.watres.2009.08.002 |
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| Title | Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data |
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