Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups...

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Vydáno v:	Arquivos de neuro-psiquiatria Ročník 70; číslo 11; s. 874 - 879
Hlavní autoři:	Sadeghian, Reihaneh, Fereidoni, Masoud, Soukhtanloo, Mohammad, Azizi-Malekabadi, Hamid, Hosseini, Mahmoud
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Brazil Academia Brasileira de Neurologia - ABNEURO 01.11.2012 Thieme Revinter Publicações
Témata:	Analysis of Variance Animals Contraceptive Agents - administration & dosage Dose-Response Relationship, Drug estradiol Estradiol - administration & dosage Estradiol - analogs & derivatives Female hipocampo Hippocampus - drug effects Hippocampus - metabolism Humans Learning Disorders - etiology Learning Disorders - metabolism Maze Learning - drug effects Memory - drug effects Memory Disorders - etiology Memory Disorders - metabolism NEUROSCIENCES Nitric Oxide - biosynthesis Nitric Oxide - metabolism Ovariectomy PSYCHIATRY Random Allocation rato Rats Rats, Wistar óxido nítrico óxido nítrico nitric oxide hipocampo rat hippocampus estradiol rato
ISSN:	0004-282X, 1678-4227, 0004-282X, 1678-4227
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