Absence of a gender gap in survival. An analysis of the Italian registry for cystic fibrosis in the paediatric age
The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged. We evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Re...
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| Veröffentlicht in: | Journal of cystic fibrosis Jg. 10; H. 5; S. 313 - 317 |
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01.09.2011
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| ISSN: | 1569-1993, 1873-5010, 1873-5010 |
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| Abstract | The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.
We evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Registry for CF (IRCF).
We observed similar annual mortality rates in females (3.59‰) and males (4.00‰), similar survival curves (log-rank test p
=
0.64) and similar hazards of death (hazard ratio adjusted for presence of symptoms at diagnosis, meconium ileus, F508del mutation and age at diagnosis: 1.29, 95%CI: 0.60; 2.76). However, excess mortality due to CF was higher for females (5.9) than males (5.1).
In our population CF females do not experience higher mortality than males but, due to the disease, they lose the expected survival advantage occurring in the general population at this age. We do not exclude, however, that differences in mortality will establish after adolescence. |
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| AbstractList | The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.
We evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Registry for CF (IRCF).
We observed similar annual mortality rates in females (3.59‰) and males (4.00‰), similar survival curves (log-rank test p
=
0.64) and similar hazards of death (hazard ratio adjusted for presence of symptoms at diagnosis, meconium ileus, F508del mutation and age at diagnosis: 1.29, 95%CI: 0.60; 2.76). However, excess mortality due to CF was higher for females (5.9) than males (5.1).
In our population CF females do not experience higher mortality than males but, due to the disease, they lose the expected survival advantage occurring in the general population at this age. We do not exclude, however, that differences in mortality will establish after adolescence. The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged. We evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Registry for CF (IRCF). We observed similar annual mortality rates in females (3.59‰) and males (4.00‰), similar survival curves (log-rank test p=0.64) and similar hazards of death (hazard ratio adjusted for presence of symptoms at diagnosis, meconium ileus, F508del mutation and age at diagnosis: 1.29, 95%CI: 0.60; 2.76). However, excess mortality due to CF was higher for females (5.9) than males (5.1). In our population CF females do not experience higher mortality than males but, due to the disease, they lose the expected survival advantage occurring in the general population at this age. We do not exclude, however, that differences in mortality will establish after adolescence. The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.BACKGROUNDThe existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.We evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Registry for CF (IRCF).METHODSWe evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Registry for CF (IRCF).We observed similar annual mortality rates in females (3.59‰) and males (4.00‰), similar survival curves (log-rank test p=0.64) and similar hazards of death (hazard ratio adjusted for presence of symptoms at diagnosis, meconium ileus, F508del mutation and age at diagnosis: 1.29, 95%CI: 0.60; 2.76). However, excess mortality due to CF was higher for females (5.9) than males (5.1).RESULTSWe observed similar annual mortality rates in females (3.59‰) and males (4.00‰), similar survival curves (log-rank test p=0.64) and similar hazards of death (hazard ratio adjusted for presence of symptoms at diagnosis, meconium ileus, F508del mutation and age at diagnosis: 1.29, 95%CI: 0.60; 2.76). However, excess mortality due to CF was higher for females (5.9) than males (5.1).In our population CF females do not experience higher mortality than males but, due to the disease, they lose the expected survival advantage occurring in the general population at this age. We do not exclude, however, that differences in mortality will establish after adolescence.CONCLUSIONSIn our population CF females do not experience higher mortality than males but, due to the disease, they lose the expected survival advantage occurring in the general population at this age. We do not exclude, however, that differences in mortality will establish after adolescence. Abstract Background The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged. Methods We evaluated the effect of gender on survival of 2293 CF patients born after 01/01/1988, followed up by 29 CF centres until 31/12/2004 and recorded in the Italian Registry for CF (IRCF). Results We observed similar annual mortality rates in females (3.59‰) and males (4.00‰), similar survival curves (log-rank test p = 0.64) and similar hazards of death (hazard ratio adjusted for presence of symptoms at diagnosis, meconium ileus, F508del mutation and age at diagnosis: 1.29, 95%CI: 0.60; 2.76). However, excess mortality due to CF was higher for females (5.9) than males (5.1). Conclusions In our population CF females do not experience higher mortality than males but, due to the disease, they lose the expected survival advantage occurring in the general population at this age. We do not exclude, however, that differences in mortality will establish after adolescence. |
| Author | Bossi, Anna Viviani, Laura Assael, Baroukh Maurice |
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| Cites_doi | 10.2337/diacare.28.7.1581 10.1016/S0022-3476(98)70171-4 10.1164/rccm.200505-840OE 10.1093/oxfordjournals.aje.a009172 10.1093/aje/kwf064 10.1093/aje/kwf014 10.1016/S0022-3476(98)70344-0 10.1017/S0003480097006477 10.1353/hub.2004.0040 10.1183/09031936.00099506 10.1016/0895-4356(94)00230-N 10.1002/ppul.10230 10.1093/oxfordjournals.aje.a008664 10.1067/mpd.2003.197 10.1002/humu.10041 10.1016/S0012-3692(15)52709-8 |
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| Copyright | 2011 European Cystic Fibrosis Society European Cystic Fibrosis Society Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
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| Snippet | The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.
We evaluated the effect... Abstract Background The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.... The existence of gender-related differences since childhood in survival of cystic fibrosis (CF) patients has been recently challenged.BACKGROUNDThe existence... |
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| SubjectTerms | Adolescent Age Distribution Child Child, Preschool Cystic Fibrosis - epidemiology Female Humans Incidence Infant Italy - epidemiology Kaplan-Meier Estimate Longitudinal Studies Male Pulmonary/Respiratory Registries - statistics & numerical data Risk Factors Sex Distribution |
| Title | Absence of a gender gap in survival. An analysis of the Italian registry for cystic fibrosis in the paediatric age |
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