Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice

Cortical spreading depression, which plays an important role in multiple neurological disorders, has been studied primarily with experimental models that use highly invasive methods. We developed a relatively non-invasive optogenetic model to induce cortical spreading depression by transcranial stim...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism Vol. 37; no. 5; pp. 1641 - 1655
Main Authors:	Houben, Thijs, Loonen, Inge Cm, Baca, Serapio M, Schenke, Maarten, Meijer, Johanna H, Ferrari, Michel D, Terwindt, Gisela M, Voskuyl, Rob A, Charles, Andrew, van den Maagdenberg, Arn Mjm, Tolner, Else A
Format:	Journal Article
Language:	English
Published:	United States 01.05.2017
Subjects:	Action Potentials - physiology Anesthesia Animals Bacterial Proteins - genetics Behavior, Animal - physiology Cerebrovascular Circulation - physiology Channelrhodopsins Cortical Spreading Depression - physiology Female Laser-Doppler Flowmetry Luminescent Proteins - genetics Male Mice, Transgenic Optogenetics Photic Stimulation Recombinant Fusion Proteins - genetics vascular dynamics non-invasive Behavior electrophysiology optogenetics
ISSN:	1559-7016
Online Access:	Get more information
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