A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

Oral Diseases (2011) 17 (Suppl. 1), 42–57 Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updat...

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Vydáno v:Oral diseases Ročník 17; číslo s1; s. 42 - 57
Hlavní autoři: Kerr, AR, Warnakulasuriya, S, Mighell, AJ, Dietrich, T, Nasser, M, Rimal, J, Jalil, A, Bornstein, MM, Nagao, T, Fortune, F, Hazarey, VH, Reichart, PA, Silverman, S, Johnson, NW
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.04.2011
Wiley Subscription Services, Inc
Témata:
Dental Research - classification
Dental Research - trends
Drug therapy
Forecasting
Humans
management
medical interventions
Medical research
oral submucous fibrosis
Oral Submucous Fibrosis - drug therapy
Oral Submucous Fibrosis - therapy
Randomized Controlled Trials as Topic - standards
Research Design - standards
Studies
systematic review
Treatment Outcome
ISSN:1354-523X, 1601-0825, 1601-0825
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Shrnutí:Oral Diseases (2011) 17 (Suppl. 1), 42–57 Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updated the current medical (i.e., non‐surgical) interventions available for the management of OSF. Of the 27 published medical interventions, there were four randomized controlled trials. The overall quality of these randomized controlled studies was assessed using the GRADE approach and significant limitations that challenged the conclusions were found. However, this review was valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, and the infrastructure required to conduct studies. The next step is to initiate a pathway for a low‐cost research plan leading to the development of a brief protocol for future clinical trials in this field, with an emphasis on conducting studies in regions of the world where OSF is prevalent.
Bibliografie:istex:89AFCBFA2E619DCA08FC0F6EAC6A873671255E95
ark:/67375/WNG-7W2CF0NM-J
ArticleID:ODI1791
This manuscript is part of the outcomes of the World Workshop on Oral Medicine V. (2010)
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ISSN:1354-523X
1601-0825
1601-0825
DOI:10.1111/j.1601-0825.2011.01791.x