Using Metagenomics to Characterize an Expanding Virosphere

We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterizati...

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Vydáno v:Cell Ročník 172; číslo 6; s. 1168
Hlavní autoři: Zhang, Yong-Zhen, Shi, Mang, Holmes, Edward C
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 08.03.2018
Témata:
Evolution, Molecular
Genetic Variation
Genome, Viral - genetics
Metagenomics - methods
Phylogeny
RNA Viruses - classification
RNA Viruses - genetics
Viruses - classification
Viruses - genetics
ISSN:1097-4172, 1097-4172
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Shrnutí:We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterization of the "dark matter" of divergent viral genomes.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2018.02.043