Using Metagenomics to Characterize an Expanding Virosphere

We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterizati...

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Bibliographic Details
Published in:Cell Vol. 172; no. 6; p. 1168
Main Authors: Zhang, Yong-Zhen, Shi, Mang, Holmes, Edward C
Format: Journal Article
Language:English
Published: United States 08.03.2018
Subjects:
Evolution, Molecular
Genetic Variation
Genome, Viral - genetics
Metagenomics - methods
Phylogeny
RNA Viruses - classification
RNA Viruses - genetics
Viruses - classification
Viruses - genetics
ISSN:1097-4172, 1097-4172
Online Access:Get more information
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Summary:We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterization of the "dark matter" of divergent viral genomes.
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2018.02.043