One Year Follow-Up of COVID-19 Related Symptoms and Patient Quality of Life: A Prospective Cohort Study

Globally, concerns have grown regarding the long-term effects of novel coronavirus disease (COVID-19) infection. Therefore, we evaluated the long-term course of persistent symptoms and patient quality of life. This prospective cohort study was conducted at a single tertiary university hospital from...

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Vydáno v:Yonsei medical journal Ročník 63; číslo 6; s. 499 - 510
Hlavní autoři: Kim, Yoonjung, Kim, Shin-Woo, Chang, Hyun-Ha, Kwon, Ki Tae, Hwang, Soyoon, Bae, Sohyun
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) Yonsei University College of Medicine 01.06.2022
연세대학교의과대학
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Original
의학일반
COVID-19
SARS-CoV-2
life quality
health-related quality of life
long COVID
long-term consequences
persistent symptoms
ISSN:0513-5796, 1976-2437, 1976-2437
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Shrnutí:Globally, concerns have grown regarding the long-term effects of novel coronavirus disease (COVID-19) infection. Therefore, we evaluated the long-term course of persistent symptoms and patient quality of life. This prospective cohort study was conducted at a single tertiary university hospital from August 31, 2020 to March 29, 2021 with adult patients followed at 6 and 12 months after acute COVID-19 symptom onset or diagnosis. Clinical characteristics, self-reported symptoms, EuroQol 5 dimension 5 level (EQ5D-5L) index scores, Korean version of the Patient Health Questionnaire-9 (PHQ-9), Korean version of the Posttraumatic Stress Disorder Checklist-5 (PCL-5-K), and Generalized Anxiety Disorder-7 (GAD-7) were investigated. Symptom persistent or non-persistent groups were defined according to persistency of COVID-19 related symptoms or signs after acute COVID-19 infection, respectively. Of all 235 patients, 170 (64.6%) patients were eligible for analysis. The median age was 51 (interquartile range, 37-61) years old, and 102 patients were female (60.0%). After 12 months from acute COVID-19 infection, in total, 83 (48.8%) patients still suffered from COVID-19-related symptoms. The most common symptoms included amnesia (24.1%), insomnia (14.7%), fatigue (13.5%), and anxiety (12.9%). Among the five EQ5D-5L categories, the average value of anxiety or depression was the most predominant. PHQ-9 and PCL-5-K scores were statistically higher in the COVID-19-related symptom persistent group than the non-persistent group ( =0.001). However, GAD-7 scores showed no statistical differences between the two groups ( =0.051). Neuropsychiatric symptoms were the major COVID-19-related symptoms after 12 months from acute COVID-19 infection, reducing quality of life.
Bibliografie:ObjectType-Article-1
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https://www.eymj.org/DOIx.php?id=10.3349/ymj.2022.63.6.499
ISSN:0513-5796
1976-2437
1976-2437
DOI:10.3349/ymj.2022.63.6.499