DHEA Alleviates Oxidative Stress of Muscle Cells via Activation of Nrf2 Pathway

Dehydroepiandrosterone (DHEA) has been proposed to regulate muscle dystrophy, while the underlying mechanisms for its protection against muscle atrophy are unknown. The present study was carried out to improve our understanding of the mechanism of DHEA’s protective effect on muscle cells. We observe...

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Bibliographic Details
Published in:	Applied biochemistry and biotechnology Vol. 176; no. 1; pp. 22 - 32
Main Authors:	Jeon, Songhee, Hur, Jinyoung, Kim, Jongpil
Format:	Journal Article
Language:	English
Published:	New York Springer-Verlag 01.05.2015 Springer US Springer Nature B.V
Subjects:	Animals anti-inflammatory activity antioxidant activity Antioxidants Biochemistry Biotechnology cell death Cell Line Cells Chemistry Chemistry and Materials Science Dehydroepiandrosterone - pharmacology dose response Dystrophy genes Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hydrogen peroxide Hydrogen Peroxide - pharmacology MAP Kinase Signaling System - drug effects Membrane Proteins - genetics Membrane Proteins - metabolism Mice mitogen-activated protein kinase Muscle Proteins - genetics Muscle Proteins - metabolism muscles muscular atrophy Muscular Atrophy - drug therapy Muscular Atrophy - genetics Muscular Atrophy - metabolism Muscular Atrophy - pathology Muscular system Myoblasts - metabolism Myoblasts - pathology myocytes NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism phosphorylation prasterone protective effect reactive oxygen species Toxicity Oxidative stress HO-1 C cells p38 Nrf2
ISSN:	0273-2289, 1559-0291, 1559-0291
Online Access:	Get full text
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