Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly

Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular insights into the NC assembly process are lacking. Using a hybrid approach, we characterized the NC-like assembly of eN...

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Veröffentlicht in:	Cell Jg. 172; H. 5; S. 966
Hauptverfasser:	Su, Zhaoming, Wu, Chao, Shi, Liuqing, Luthra, Priya, Pintilie, Grigore D, Johnson, Britney, Porter, Justin R, Ge, Peng, Chen, Muyuan, Liu, Gai, Frederick, Thomas E, Binning, Jennifer M, Bowman, Gregory R, Zhou, Z Hong, Basler, Christopher F, Gross, Michael L, Leung, Daisy W, Chiu, Wah, Amarasinghe, Gaya K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.02.2018
Schlagworte:	Cryoelectron Microscopy Ebolavirus - physiology Ebolavirus - ultrastructure Models, Biological Mutant Proteins - chemistry Mutation - genetics Nucleocapsid - ultrastructure Nucleoproteins - chemistry Nucleoproteins - ultrastructure Protein Multimerization Protein Structure, Secondary Protein Subunits - chemistry Protein Subunits - metabolism RNA, Viral - biosynthesis RNA, Viral - chemistry RNA, Viral - metabolism Virus Assembly Ebola virus nucleocapsid nucleoprotein viral RNA synthesis cryo-EM
ISSN:	1097-4172, 1097-4172
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