Polygenic type 2 diabetes prediction at the limit of common variant detection

Genome-wide association studies (GWAS) may have reached their limit of detecting common type 2 diabetes (T2D)-associated genetic variation. We evaluated the performance of current polygenic T2D prediction. Using data from the Framingham Offspring (FOS) and the Coronary Artery Risk Development in You...

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Vydáno v:	Diabetes (New York, N.Y.) Ročník 63; číslo 6; s. 2172
Hlavní autoři:	Vassy, Jason L, Hivert, Marie-France, Porneala, Bianca, Dauriz, Marco, Florez, Jose C, Dupuis, Josée, Siscovick, David S, Fornage, Myriam, Rasmussen-Torvik, Laura J, Bouchard, Claude, Meigs, James B
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.06.2014
Témata:	Adolescent Adult Aged Black or African American - genetics Child Child, Preschool Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Environmental Exposure Female Follow-Up Studies Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Genotype Humans Insulin Resistance - genetics Male Middle Aged Obesity - complications Obesity - genetics Polymorphism, Single Nucleotide Proportional Hazards Models Prospective Studies Risk Factors Sedentary Behavior White People - genetics
ISSN:	1939-327X, 1939-327X
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