Host–microbe interactions in distal airways: relevance to chronic airway diseases

This article is the summary of a workshop, which took place in November 2013, on the roles of microorganisms in chronic respiratory diseases. Until recently, it was assumed that lower airways were sterile in healthy individuals. However, it has long been acknowledged that microorganisms could be ide...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	European respiratory review Ročník 24; číslo 135; s. 78 - 91
Hlavní autori:	Martin, Clémence, Burgel, Pierre-Régis, Lepage, Patricia, Andréjak, Claire, Blic, Jacques de, Bourdin, Arnaud, Brouard, Jacques, Chanez, Pascal, Dalphin, Jean-Charles, Deslée, Gaetan, Deschildre, Antoine, Gosset, Philippe, Touqui, Lhousseine, Dusser, Daniel
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England European Respiratory Society 01.03.2015
Predmet:	Asthma - microbiology Asthma - virology Bronchiectasis - microbiology Cystic Fibrosis - microbiology Cystic Fibrosis - virology Gastrointestinal Microbiome Host-Pathogen Interactions Humans Life Sciences Lung - microbiology Microbiota Mycobacterium - pathogenicity Pulmonary Disease, Chronic Obstructive - microbiology Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory Tract Diseases - microbiology Respiratory Tract Diseases - physiopathology Reviews
ISSN:	0905-9180, 1600-0617
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	This article is the summary of a workshop, which took place in November 2013, on the roles of microorganisms in chronic respiratory diseases. Until recently, it was assumed that lower airways were sterile in healthy individuals. However, it has long been acknowledged that microorganisms could be identified in distal airway secretions from patients with various respiratory diseases, including cystic fibrosis (CF) and non-CF bronchiectasis, chronic obstructive pulmonary disease, asthma and other chronic airway diseases ( e.g. post-transplantation bronchiolitis obliterans). These microorganisms were sometimes considered as infectious agents that triggered host immune responses and contributed to disease onset and/or progression; alternatively, microorganisms were often considered as colonisers, which were considered unlikely to play roles in disease pathophysiology. These concepts were developed at a time when the identification of microorganisms relied on culture-based methods. Importantly, the majority of microorganisms cannot be cultured using conventional methods, and the use of novel culture-independent methods that rely on the identification of microorganism genomes has revealed that healthy distal airways display a complex flora called the airway microbiota. The present article reviews some aspects of current literature on host–microbe (mostly bacteria and viruses) interactions in healthy and diseased airways, with a special focus on distal airways.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0905-9180 1600-0617
DOI:	10.1183/09059180.00011614