Projection Profiling: A Data Compressing Strategy in Three-Dimensional Liquid Chromatography for Quality Control of Traditional Herbal Medicine

Chromatographic fingerprint technology has become the standard of quality control for traditional herbal medicines (THMs). But several issues are associated with the wavelength selection of the representative fingerprint, such as contradictory evaluation results at different wavelengths and the accu...

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Veröffentlicht in:Sensors (Basel, Switzerland) Jg. 25; H. 7; S. 2015
1. Verfasser: Zhang, Jing
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 23.03.2025
MDPI
Schlagworte:
Algorithms
Analysis
analytical method validation
Automation
baseline correction
Biometry
Chromatography
Chromatography, Liquid - methods
Data compression
Data processing
Drugs
Drugs, Chinese Herbal
Glycyrrhiza - chemistry
Herbal Medicine
Liquid chromatography
Medicine, Botanic
Medicine, Herbal
Methods
Nonparametric statistics
projection profiling
Quality Control
traditional herbal medicine
China
analytical method validation
projection profiling
quality control
baseline correction
traditional herbal medicine
ISSN:1424-8220, 1424-8220
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Zusammenfassung:Chromatographic fingerprint technology has become the standard of quality control for traditional herbal medicines (THMs). But several issues are associated with the wavelength selection of the representative fingerprint, such as contradictory evaluation results at different wavelengths and the accurate quantification of each composition at one wavelength. These problems can be addressed by projection profiling. Projection profiling is a collection of all sample compositions at the maximum absorption wavelength after baseline correction. In this paper, eleven baseline correction algorithms are optimized by using the effective information factor (EI) as an indicator. The influence of different integration methods and wavelengths on analytical method validation and similarity analysis results are discussed in detail to clarify the advantages of the projection profiling. A total of 33 batches of Compound Licorice Tablets (CLTs) were used to show the influence of different wavelengths in a similarity evaluation. The results show that projection profiling is a better choice than any chromatogram at a certain wavelength, because projection profiling is more informative, accurate, and stable.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1424-8220
1424-8220
DOI:10.3390/s25072015