Protective Role of Chronic Exercise Training in Modulating the Impact of Hyperglycemia on Vascular Sensitivity to Ischemia-Reperfusion

Hyperglycemia (HG) is associated with increased mortality and morbidity in acute ischemic events. Regardless of the tissue or organs involved, the vascular endothelium is a key target of ischemia-reperfusion (I/R) injury severity. Among endothelium-protective strategies, exercise has been widely des...

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Bibliographic Details
Published in:Nutrients Vol. 15; no. 1; p. 212
Main Authors: Grandperrin, Antoine, Bourgoin, Mathilde, Gayrard, Sandrine, Boulghobra, Doria, Walther, Guillaume, Reboul, Cyril, Meyer, Grégory
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.01.2023
MDPI
Subjects:
Animals
bioavailability
blood flow
Cardiovascular diseases
Care and treatment
Complications and side effects
Development and progression
Endothelium
Endothelium, Vascular
Exercise
Fitness training programs
Health aspects
Hyperglycemia
Ischemia
Ischemia - complications
Laboratory animals
Life Sciences
Male
males
mortality
nitric oxide
Oxidative stress
Physiological aspects
Prevention
protective effect
Rats
Rats, Wistar
Reactive oxygen species
Reperfusion
Reperfusion Injury - complications
Reperfusion Injury - prevention & control
Risk factors
streptozotocin
Variance analysis
Vascular endothelium
Veins & arteries
France
United States > US
ischemia reperfusion
hyperglycemia
vascular function
exercise
Meyer
M. Gayrard
Bourgoin
C. Meyer
D. Walther
Walther
Boulghobra
G. Reboul
G exercise vascular function hyperglycemia ischemia reperfusion
A. Bourgoin
Reboul
Gayrard
S. Boulghobra
ISSN:2072-6643, 2072-6643
Online Access:Get full text
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Summary:Hyperglycemia (HG) is associated with increased mortality and morbidity in acute ischemic events. Regardless of the tissue or organs involved, the vascular endothelium is a key target of ischemia-reperfusion (I/R) injury severity. Among endothelium-protective strategies, exercise has been widely described as useful. However, whether this strategy is able to impact the deleterious effect of HG on endothelial function during I/R has never been challenged. For this, 48 male Wistar rats were randomized into 4 groups: sedentary (Sed) or exercised (Ex, 45 min/day, 5 days/week for 5 weeks) rats, treated (hyperglycemic, HG) or not (normoglycemic, NG) with streptozotocin (40 mg/kg, 48 h before procedure). Vascular I/R (120/15 min) was performed by clamping the femoral artery. Arterial and downstream muscular perfusions were assessed using laser speckle contrast imaging. Vascular endothelial function was assessed in vivo 15 min after reperfusion. HG was responsible for impairment of reperfusion blood flow as well as endothelial function. Interestingly exercise was able to prevent those impairments in the HG group. In agreement with the previous results, HG increased reactive oxygen species production and decreased nitric oxide bioavailability whereas exercise training normalized these parameters. It, therefore, appears that exercise may be an effective prevention strategy against the exacerbation of vascular and muscular damage by hyperglycemia during I/R.
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These authors contributed equally to this work.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15010212