A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of human mammary epithelial organoids. Using this protocol, >100 primary and metastatic BC organoid lines were generated, br...

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Veröffentlicht in:	Cell Jg. 172; H. 1-2; S. 373
Hauptverfasser:	Sachs, Norman, de Ligt, Joep, Kopper, Oded, Gogola, Ewa, Bounova, Gergana, Weeber, Fleur, Balgobind, Anjali Vanita, Wind, Karin, Gracanin, Ana, Begthel, Harry, Korving, Jeroen, van Boxtel, Ruben, Duarte, Alexandra Alves, Lelieveld, Daphne, van Hoeck, Arne, Ernst, Robert Frans, Blokzijl, Francis, Nijman, Isaac Johannes, Hoogstraat, Marlous, van de Ven, Marieke, Egan, David Anthony, Zinzalla, Vittoria, Moll, Jurgen, Boj, Sylvia Fernandez, Voest, Emile Eugene, Wessels, Lodewyk, van Diest, Paul Joannes, Rottenberg, Sven, Vries, Robert Gerhardus Jacob, Cuppen, Edwin, Clevers, Hans
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.01.2018
Schlagworte:	Animals Antineoplastic Agents - pharmacology Breast Neoplasms - genetics Breast Neoplasms - pathology Cells, Cultured Drug Screening Assays, Antitumor - methods Female Genetic Heterogeneity Humans Mice Mice, Nude Organoids - drug effects Organoids - pathology Precision Medicine - methods Tissue Banks organoids triple negative breast cancer precision medicine basal biobank luminal
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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