NF-κB: At the Borders of Autoimmunity and Inflammation

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response. In the first part of this review, we discuss the NF-κB inducers, signaling pathways, and regulators involved in immune homeostasis as well as d...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 12; p. 716469
Main Authors:	Barnabei, Laura, Laplantine, Emmanuel, Mbongo, William, Rieux-Laucat, Frédéric, Weil, Robert
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers 09.08.2021 Frontiers Media S.A
Subjects:	Animals Autoimmune Diseases - etiology Autoimmune Diseases - metabolism autoimmunity Autoimmunity - genetics autoinflammation Carrier Proteins - metabolism Disease Management Disease Susceptibility genetic diseases Genetic Predisposition to Disease Humans Immune Checkpoint Proteins - genetics Immune Tolerance Immunology Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation - therapy Life Sciences Molecular Targeted Therapy NF-kappa B - genetics NF-kappa B - metabolism NF-κB Protein Binding Signal Transduction T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Ubiquitin-Protein Ligases - metabolism ubiquitination genetic diseases autoinflammation NF-κB immune tolerance autoimmunity ubiquitination NF-kB
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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