NF-κB: At the Borders of Autoimmunity and Inflammation

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response. In the first part of this review, we discuss the NF-κB inducers, signaling pathways, and regulators involved in immune homeostasis as well as d...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology Vol. 12; p. 716469
Main Authors: Barnabei, Laura, Laplantine, Emmanuel, Mbongo, William, Rieux-Laucat, Frédéric, Weil, Robert
Format: Journal Article
Language:English
Published: Switzerland Frontiers 09.08.2021
Frontiers Media S.A
Subjects:
Animals
Autoimmune Diseases - etiology
Autoimmune Diseases - metabolism
autoimmunity
Autoimmunity - genetics
autoinflammation
Carrier Proteins - metabolism
Disease Management
Disease Susceptibility
genetic diseases
Genetic Predisposition to Disease
Humans
Immune Checkpoint Proteins - genetics
Immune Tolerance
Immunology
Inflammation - etiology
Inflammation - metabolism
Inflammation - pathology
Inflammation - therapy
Life Sciences
Molecular Targeted Therapy
NF-kappa B - genetics
NF-kappa B - metabolism
NF-κB
Protein Binding
Signal Transduction
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Ubiquitin-Protein Ligases - metabolism
ubiquitination
genetic diseases
autoinflammation
NF-κB
immune tolerance
autoimmunity
ubiquitination
NF-kB
ISSN:1664-3224, 1664-3224
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response. In the first part of this review, we discuss the NF-κB inducers, signaling pathways, and regulators involved in immune homeostasis as well as detail the importance of post-translational regulation by ubiquitination in NF-κB function. We also indicate the stages of central and peripheral tolerance where NF-κB plays a fundamental role. With respect to central tolerance, we detail how NF-κB regulates medullary thymic epithelial cell (mTEC) development, homeostasis, and function. Moreover, we elaborate on its role in the migration of double-positive (DP) thymocytes from the thymic cortex to the medulla. With respect to peripheral tolerance, we outline how NF-κB contributes to the inactivation and destruction of autoreactive T and B lymphocytes as well as the differentiation of CD4 + -T cell subsets that are implicated in immune tolerance. In the latter half of the review, we describe the contribution of NF-κB to the pathogenesis of autoimmunity and autoinflammation. The recent discovery of mutations involving components of the pathway has both deepened our understanding of autoimmune disease and informed new therapeutic approaches to treat these illnesses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
Edited by: Howard A Young, National Cancer Institute at Frederick, United States
Reviewed by: Ruaidhri Carmody, University of Glasgow, United Kingdom; Patrick Leung, University of California, Davis, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.716469