Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants

The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective vaccination campaigns have reduced the fatalities associated with SARS-CoV-2, infections continue, and a detailed understanding of how this virus mani...

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Veröffentlicht in:	Journal of lipid research Jg. 66; H. 8; S. 100860
Hauptverfasser:	Farley, Scotland E., Kyle, Jennifer E., Jahn, Helene, Bramer, Lisa M., Piehowski, Paul D., Shepmoes, Athena A., Kaiser, Brooke LD, Williams, Sarai M., Eder, Josie G., Schultz, Carsten, Tafesse, Fikadu G.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.08.2025 Elsevier BV American Society for Biochemistry and Molecular Biology Elsevier
Schlagworte:	A549 Cells ceramides coronavirus COVID-19 - metabolism COVID-19 - virology host-virus interaction Humans Lipid Metabolism Lipidomics Metabolic Networks and Pathways neutral lipids Proteome - metabolism Proteomics SARS-CoV-2 SARS-CoV-2 - metabolism SARS-CoV-2 - physiology SARS-CoV-2 variants sphingolipids proteomics sphingolipids DTT lipid metabolism SARS-CoV-2 variants HCD coronavirus host-virus interaction DAG LIPA ceramides AACS FADS3 SARS-CoV-2 FASN SPT TAG lipidomics neutral lipids
ISSN:	0022-2275, 1539-7262, 1539-7262
Online-Zugang:	Volltext
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