TIGRFAMs: a protein family resource for the functional identification of proteins
TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members o...
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| Published in: | Nucleic acids research Vol. 29; no. 1; pp. 41 - 43 |
|---|---|
| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Oxford Publishing Limited (England)
01.01.2001
Oxford University Press |
| Subjects: | |
| ISSN: | 1362-4962, 0305-1048, 1362-4962 |
| Online Access: | Get full text |
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| Abstract | TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members of a set of homologous proteins that are conserved with respect to function since their last common ancestor. Related proteins are grouped into equivalog families where possible, and otherwise into protein families with other hierarchically defined homology types. TIGRFAMs currently contains over 800 protein families, available for searching or downloading at www.tigr.org/TIGRFAMs. Classification by equivalog family, where achievable, complements classification by orthology, superfamily, domain or motif. It provides the information best suited for automatic assignment of specific functions to proteins from large-scale genome sequencing projects. |
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| AbstractList | TIGRFAMs is a collection of protein families featuring curated
multiple sequence alignments, hidden Markov models and associated
information designed to support the automated functional identification
of proteins by sequence homology. We introduce the term ‘equivalog’ to
describe members of a set of homologous proteins that are conserved
with respect to function since their last common ancestor. Related proteins
are grouped into equivalog families where possible, and otherwise
into protein families with other hierarchically defined homology
types. TIGRFAMs currently contains over 800 protein families, available
for searching or downloading at www.tigr.org/TIGRFAMs. Classification
by equivalog family, where achievable, complements classification
by orthology, superfamily, domain or motif. It provides the information best
suited for automatic assignment of specific functions to proteins
from large-scale genome sequencing projects. TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term `equivalog' to describe members of a set of homologous proteins that are conserved with respect to function since their last common ancestor. Related proteins are grouped into equivalog families where possible, and otherwise into protein families with other hierarchically defined homology types. TIGRFAMs currently contains over 800 protein families, available for searching or downloading at www.tigr.org/TIGRFAMs. Classification by equivalog family, where achievable, complements classification by orthology, superfamily, domain or motif. It provides the information best suited for automatic assignment of specific functions to proteins from large-scale genome sequencing projects. TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members of a set of homologous proteins that are conserved with respect to function since their last common ancestor. Related proteins are grouped into equivalog families where possible, and otherwise into protein families with other hierarchically defined homology types. TIGRFAMs currently contains over 800 protein families, available for searching or downloading at www.tigr.org/TIGRFAMs. Classification by equivalog family, where achievable, complements classification by orthology, superfamily, domain or motif. It provides the information best suited for automatic assignment of specific functions to proteins from large-scale genome sequencing projects.TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members of a set of homologous proteins that are conserved with respect to function since their last common ancestor. Related proteins are grouped into equivalog families where possible, and otherwise into protein families with other hierarchically defined homology types. TIGRFAMs currently contains over 800 protein families, available for searching or downloading at www.tigr.org/TIGRFAMs. Classification by equivalog family, where achievable, complements classification by orthology, superfamily, domain or motif. It provides the information best suited for automatic assignment of specific functions to proteins from large-scale genome sequencing projects. |
| Author | Haft, D. H. |
| AuthorAffiliation | The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA |
| AuthorAffiliation_xml | – name: The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA |
| Author_xml | – sequence: 1 givenname: D. H. surname: Haft fullname: Haft, D. H. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11125044$$D View this record in MEDLINE/PubMed |
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| Snippet | TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to... TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to... |
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| SubjectTerms | Databases, Factual Internet Markov chains Phylogeny Proteins Proteins - genetics Sequence Alignment TIGRFAM |
| Title | TIGRFAMs: a protein family resource for the functional identification of proteins |
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