Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1

The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T,...

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Bibliographic Details
Published in:Journal of virology Vol. 78; no. 8; p. 3846
Main Authors: Vollstedt, Sabine, Arnold, Susi, Schwerdel, Cornelia, Franchini, Marco, Alber, Gottfried, Di Santo, James P, Ackermann, Mathias, Suter, Mark
Format: Journal Article
Language:English
Published: United States 01.04.2004
Subjects:
Animals
B-Lymphocytes - immunology
Central Nervous System Infections - immunology
Central Nervous System Infections - virology
DNA, Viral - isolation & purification
Herpes Simplex - immunology
Herpes Simplex - virology
Herpesvirus 1, Human - immunology
Herpesvirus 1, Human - isolation & purification
Herpesvirus 1, Human - pathogenicity
Interferon gamma Receptor
Interferons - physiology
Killer Cells, Natural - immunology
Lymphocyte Subsets - immunology
Membrane Proteins
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Knockout
Receptor, Interferon alpha-beta
Receptors, Interferon - deficiency
Receptors, Interferon - genetics
Receptors, Interferon - physiology
T-Lymphocytes - immunology
ISSN:0022-538X
Online Access:Get more information
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Summary:The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T, or NK cells. IFN-alpha/beta and IFN-gamma cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.
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ISSN:0022-538X
DOI:10.1128/JVI.78.8.3846-3850.2004